Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Lifo Ruan; Jun Chen; Chuanchao Du; Huiru Lu; Jiayu Zhang; Xiaomeng Cai; Rui Dou; Wenchu Lin; Zhifang Chai; Guangjun Nie; Yi Hu

doi:10.1016/j.bioactmat.2021.10.045

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Lifo Ruan, Jun Chen, Chuanchao Du, Huiru Lu, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Wenchu Lin, Zhifang Chai, Guangjun Nie, Yi Hu

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

Original language	English (US)
Pages (from-to)	191-199
Number of pages	9
Journal	Bioactive Materials
Volume	13
DOIs	https://doi.org/10.1016/j.bioactmat.2021.10.045
State	Published - Jul 2022

Keywords

Drug delivery
Drug resistance
Mitochondrial temperature
Nanomedicines
Thermoresponsive

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biomedical Engineering

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10.1016/j.bioactmat.2021.10.045

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title = "Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer",

abstract = "Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.",

keywords = "Drug delivery, Drug resistance, Mitochondrial temperature, Nanomedicines, Thermoresponsive",

author = "Lifo Ruan and Jun Chen and Chuanchao Du and Huiru Lu and Jiayu Zhang and Xiaomeng Cai and Rui Dou and Wenchu Lin and Zhifang Chai and Guangjun Nie and Yi Hu",

note = "Funding Information: We are grateful to Beijing Natural Science Foundation ( 7212212 ), National Natural Science Foundation of China ( 11875269 and 21574136 ), and Hundred Talents Program of CAS for financial support. Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

month = jul,

doi = "10.1016/j.bioactmat.2021.10.045",

language = "English (US)",

volume = "13",

pages = "191--199",

journal = "Bioactive Materials",

issn = "2452-199X",

publisher = "KeAi Communications Co.",

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TY - JOUR

T1 - Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

AU - Ruan, Lifo

AU - Chen, Jun

AU - Du, Chuanchao

AU - Lu, Huiru

AU - Zhang, Jiayu

AU - Cai, Xiaomeng

AU - Dou, Rui

AU - Lin, Wenchu

AU - Chai, Zhifang

AU - Nie, Guangjun

AU - Hu, Yi

N1 - Funding Information: We are grateful to Beijing Natural Science Foundation ( 7212212 ), National Natural Science Foundation of China ( 11875269 and 21574136 ), and Hundred Talents Program of CAS for financial support. Publisher Copyright: © 2021 The Authors

PY - 2022/7

Y1 - 2022/7

N2 - Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

AB - Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

KW - Drug delivery

KW - Drug resistance

KW - Mitochondrial temperature

KW - Nanomedicines

KW - Thermoresponsive

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DO - 10.1016/j.bioactmat.2021.10.045

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VL - 13

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EP - 199

JO - Bioactive Materials

JF - Bioactive Materials

ER -

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Abstract

Keywords

ASJC Scopus subject areas

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