MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

D. S. Chu; D. L. Sellers; M. J. Bocek; A. E. Fischedick; P. J. Horner; S. H. Pun

doi:10.1039/c4bm00259h

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

D. S. Chu, D. L. Sellers, M. J. Bocek, A. E. Fischedick, P. J. Horner, S. H. Pun

Center for Neuroregeneration

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

Original language	English (US)
Pages (from-to)	41-45
Number of pages	5
Journal	Biomaterials Science
Volume	3
Issue number	1
DOIs	https://doi.org/10.1039/c4bm00259h
State	Published - Jan 1 2015

ASJC Scopus subject areas

Biomedical Engineering
Materials Science(all)

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10.1039/c4bm00259h

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abstract = "MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.",

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AU - Chu, D. S.

AU - Sellers, D. L.

AU - Bocek, M. J.

AU - Fischedick, A. E.

AU - Horner, P. J.

AU - Pun, S. H.

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AB - MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

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MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

Abstract

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