TY - JOUR
T1 - Modeling critical interaction for metastasis between circulating tumor cells (CTCs) and platelets adhered to the capillary wall
AU - Milosevic, Miljan
AU - Simic, Vladimir
AU - Nikolic, Aleksandar
AU - Shao, Ning
AU - Kawamura Hashimoto, Chihiro
AU - Godin, Biana
AU - Leonard, Fransisca
AU - Liu, Xuewu
AU - Kojic, Milos
N1 - Funding Information:
This research was funded by the Department of Defense /US Army Medical Research and National Institutes of Health (grants W81XWH2110012 and U01CA244107 ). Authors also acknowledge support from Cancer Prevention and Research Institute of Texas and Dr. and Mrs. Alan Kaplan Fund through the Houston Methodist Cancer Center. Research project was also funded by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, contract number 451-03-47/2023-01/200378 (Institute for Information Technologies Kragujevac, University of Kragujevac), Center for Scientific Research of the Serbian Academy of Sciences and Arts and the University of Kragujevac [Project MODELETS] and grant number F-134 (Serbian Academy of Sciences and Arts). We also appreciate the support from The Institute for Artificial Intelligence Research and Development of Serbia, and the City of Kragujevac, Serbia.
Funding Information:
This research was funded by the Department of Defense/US Army Medical Research and National Institutes of Health (grants W81XWH2110012 and U01CA244107). Authors also acknowledge support from Cancer Prevention and Research Institute of Texas and Dr. and Mrs. Alan Kaplan Fund through the Houston Methodist Cancer Center. Research project was also funded by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, contract number 451-03-47/2023-01/200378 (Institute for Information Technologies Kragujevac, University of Kragujevac), Center for Scientific Research of the Serbian Academy of Sciences and Arts and the University of Kragujevac [Project MODELETS] and grant number F-134 (Serbian Academy of Sciences and Arts). We also appreciate the support from The Institute for Artificial Intelligence Research and Development of Serbia, and the City of Kragujevac, Serbia.
Publisher Copyright:
© 2023
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Background and objective We used a 2D fluid-solid interaction (FSI) model to investigate the critical conditions for the arrest of the CTCs traveling through the narrowed capillary with a platelet attached to the capillary wall. This computational model allows us to determine the deformations and the progression of the passage of the CTC through different types of microvessels with platelet included. Methods The modeling process is obtained using the strong coupling approach following the remeshing procedure. Also, the 1D FE rope element for simulating active ligand-receptor bonds is implemented in our computational tool (described below). Results A relationship between the CTCs properties (size and stiffness), the platelet size and stiffness, and the ligand-receptor interaction intensity, on one side, and the time in contact between the CTCs and platelet and conditions for the cell arrest, on the other side, are determined. The model is further validated in vitro by using a microfluidic device with metastatic breast tumor cells. Conclusions The computational framework that is presented, with accompanying results, can be used as a powerful tool to study biomechanical conditions for CTCs arrest in interaction with platelets, giving a prognosis of disease progression.
AB - Background and objective We used a 2D fluid-solid interaction (FSI) model to investigate the critical conditions for the arrest of the CTCs traveling through the narrowed capillary with a platelet attached to the capillary wall. This computational model allows us to determine the deformations and the progression of the passage of the CTC through different types of microvessels with platelet included. Methods The modeling process is obtained using the strong coupling approach following the remeshing procedure. Also, the 1D FE rope element for simulating active ligand-receptor bonds is implemented in our computational tool (described below). Results A relationship between the CTCs properties (size and stiffness), the platelet size and stiffness, and the ligand-receptor interaction intensity, on one side, and the time in contact between the CTCs and platelet and conditions for the cell arrest, on the other side, are determined. The model is further validated in vitro by using a microfluidic device with metastatic breast tumor cells. Conclusions The computational framework that is presented, with accompanying results, can be used as a powerful tool to study biomechanical conditions for CTCs arrest in interaction with platelets, giving a prognosis of disease progression.
KW - Finite element analysis
KW - Fluid-solid interaction
KW - Incompressible deformations of solid
KW - CTC-platelet interaction
KW - Conditions for cell arrest
KW - Metastasis
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U2 - 10.1016/j.cmpb.2023.107810
DO - 10.1016/j.cmpb.2023.107810
M3 - Article
C2 - 37769417
SN - 0169-2607
VL - 242
JO - Computer Methods and Programs in Biomedicine
JF - Computer Methods and Programs in Biomedicine
M1 - 107810
ER -