Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development

Lars R. Furenlid; Harrison H. Barrett; H. Bradford Barber; Eric W. Clarkson; Matthew A. Kupinski; Zhonglin Liu; Gail D. Stevenson; James M. Woolfenden

doi:10.1117/12.2064808

Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development

Lars R. Furenlid, Harrison H. Barrett, H. Bradford Barber, Eric W. Clarkson, Matthew A. Kupinski, Zhonglin Liu, Gail D. Stevenson, James M. Woolfenden

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

During the past two decades, researchers at the University of Arizona's Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.

Original language	English (US)
Title of host publication	Fifty Years of Optical Sciences at the University of Arizona
Editors	John E. Greivenkamp, Eustace L. Dereniak, Harrison H. Barrett
Publisher	SPIE
ISBN (Electronic)	9781628412130
DOIs	https://doi.org/10.1117/12.2064808
State	Published - 2014
Event	50 Years of Optical Sciences at the University of Arizona - San Diego, United States Duration: Aug 19 2014 → Aug 20 2014

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	9186
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	50 Years of Optical Sciences at the University of Arizona
Country/Territory	United States
City	San Diego
Period	8/19/14 → 8/20/14

Keywords

collimation
CT
detectors
estimation
instrumentation
molecular imaging
PET
reconstruction
SPECT

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.2064808

Cite this

Furenlid, L. R., Barrett, H. H., Barber, H. B., Clarkson, E. W., Kupinski, M. A., Liu, Z., Stevenson, G. D., & Woolfenden, J. M. (2014). Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. In J. E. Greivenkamp, E. L. Dereniak, & H. H. Barrett (Eds.), Fifty Years of Optical Sciences at the University of Arizona Article 91860J (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 9186). SPIE. https://doi.org/10.1117/12.2064808

Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. / Furenlid, Lars R.; Barrett, Harrison H.; Barber, H. Bradford et al.
Fifty Years of Optical Sciences at the University of Arizona. ed. / John E. Greivenkamp; Eustace L. Dereniak; Harrison H. Barrett. SPIE, 2014. 91860J (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 9186).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Furenlid, LR, Barrett, HH, Barber, HB, Clarkson, EW, Kupinski, MA, Liu, Z, Stevenson, GD & Woolfenden, JM 2014, Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. in JE Greivenkamp, EL Dereniak & HH Barrett (eds), Fifty Years of Optical Sciences at the University of Arizona., 91860J, Proceedings of SPIE - The International Society for Optical Engineering, vol. 9186, SPIE, 50 Years of Optical Sciences at the University of Arizona, San Diego, United States, 8/19/14. https://doi.org/10.1117/12.2064808

Furenlid LR, Barrett HH, Barber HB, Clarkson EW, Kupinski MA, Liu Z et al. Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. In Greivenkamp JE, Dereniak EL, Barrett HH, editors, Fifty Years of Optical Sciences at the University of Arizona. SPIE. 2014. 91860J. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2064808

Furenlid, Lars R. ; Barrett, Harrison H. ; Barber, H. Bradford et al. / Molecular imaging in the College of Optical Sciences : An overview of two decades of instrumentation development. Fifty Years of Optical Sciences at the University of Arizona. editor / John E. Greivenkamp ; Eustace L. Dereniak ; Harrison H. Barrett. SPIE, 2014. (Proceedings of SPIE - The International Society for Optical Engineering).

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Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development

Abstract

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Keywords

ASJC Scopus subject areas

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