Monitoring of drug diffusion in ocular tissues

Mohamad G. Ghosn; Yezeng Cheng; Kirill V. Larin

doi:10.1117/12.696929

Monitoring of drug diffusion in ocular tissues

Mohamad G. Ghosn, Yezeng Cheng, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48e ^-5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.

Original language	English (US)
Title of host publication	Saratov Fall Meeting 2005
Subtitle of host publication	Optical Technologies in Biophysics and Medicine VII
DOIs	https://doi.org/10.1117/12.696929
State	Published - 2006
Event	Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII - Saratov, Russian Federation Duration: Sep 27 2005 → Sep 30 2005

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6163
ISSN (Print)	1605-7422

Conference

Conference	Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Country/Territory	Russian Federation
City	Saratov
Period	9/27/05 → 9/30/05

Keywords

Diffusion
Optical coherence tomography
Rabbit cornea

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.696929

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Ghosn, MG, Cheng, Y & Larin, KV 2006, Monitoring of drug diffusion in ocular tissues. in Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII., 616303, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, Saratov, Russian Federation, 9/27/05. https://doi.org/10.1117/12.696929

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abstract = "There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48e -5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.",

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AU - Ghosn, Mohamad G.

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N2 - There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48e -5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.

AB - There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48e -5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.

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KW - Optical coherence tomography

KW - Rabbit cornea

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SN - 9780819462152

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Saratov Fall Meeting 2005

T2 - Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII

Y2 - 27 September 2005 through 30 September 2005

ER -

Monitoring of drug diffusion in ocular tissues

Abstract

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Conference

Keywords

ASJC Scopus subject areas

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