TY - JOUR
T1 - Motor Control after Human SCI Through Activation of Muscle Synergies under Spinal Cord Stimulation
AU - Cheng, Richard
AU - Sui, Yanan
AU - Sayenko, Dimitry
AU - Burdick, Joel W.
N1 - Funding Information:
Manuscript received November 20, 2018; revised March 20, 2019; accepted April 17, 2019. Date of publication May 2, 2019; date of current version June 6, 2019. This work was supported by the National Institute of Health (NIH) under Grant EB007615. (Corresponding author: Richard Cheng.) R. Cheng and J. W. Burdick are with the Mechanical Engineering Department, California Institute of Technology, Pasadena, CA 91125 USA (e-mail: rcheng@caltech.edu).
Publisher Copyright:
© 2001-2011 IEEE.
PY - 2019/6
Y1 - 2019/6
N2 - Spinal cord stimulation (SCS) has enabled motor recovery in paraplegics with motor complete spinal cord injury (SCI). However, the physiological mechanisms underlying this recovery are unknown. This paper analyzes muscle synergies in two motor complete SCI patients under SCS during standing and compares them with muscle synergies in healthy subjects, in order to help elucidate the mechanisms that enable motor control through SCS. One challenge is that standard muscle synergy extraction algorithms, such as non-negative matrix factorization (NMF), fail when applied to SCI patients under SCS. We develop a new algorithm-rShiftNMF-to extract muscle synergies in these cases. We find muscle synergies extracted by rShiftNMF are significantly better at interpreting electromyography (EMG) activity, and resulting synergy features are more physiologically meaningful. By analyzing muscle synergies from SCI patients and healthy subjects, we find that: 1) SCI patients rely significantly on muscle synergy activation to generate motor activity; 2) interleaving SCS can selectively activate an additional muscle synergy that is critical to SCI standing; and 3) muscle synergies extracted from SCI patients under SCS differ substantially from those extracted from healthy subjects. We provide evidence that after spinal cord injury, SCS influences motor function through muscle synergy activation.
AB - Spinal cord stimulation (SCS) has enabled motor recovery in paraplegics with motor complete spinal cord injury (SCI). However, the physiological mechanisms underlying this recovery are unknown. This paper analyzes muscle synergies in two motor complete SCI patients under SCS during standing and compares them with muscle synergies in healthy subjects, in order to help elucidate the mechanisms that enable motor control through SCS. One challenge is that standard muscle synergy extraction algorithms, such as non-negative matrix factorization (NMF), fail when applied to SCI patients under SCS. We develop a new algorithm-rShiftNMF-to extract muscle synergies in these cases. We find muscle synergies extracted by rShiftNMF are significantly better at interpreting electromyography (EMG) activity, and resulting synergy features are more physiologically meaningful. By analyzing muscle synergies from SCI patients and healthy subjects, we find that: 1) SCI patients rely significantly on muscle synergy activation to generate motor activity; 2) interleaving SCS can selectively activate an additional muscle synergy that is critical to SCI standing; and 3) muscle synergies extracted from SCI patients under SCS differ substantially from those extracted from healthy subjects. We provide evidence that after spinal cord injury, SCS influences motor function through muscle synergy activation.
KW - Muscle synergy
KW - electromyography (EMG)
KW - matrix factorization
KW - spinal cord injury (SCI)
KW - spinal cord stimulation (SCI)
UR - http://www.scopus.com/inward/record.url?scp=85067246894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067246894&partnerID=8YFLogxK
U2 - 10.1109/TNSRE.2019.2914433
DO - 10.1109/TNSRE.2019.2914433
M3 - Article
C2 - 31056504
AN - SCOPUS:85067246894
SN - 1534-4320
VL - 27
SP - 1331
EP - 1340
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
IS - 6
M1 - 8704925
ER -