MRNA-enhanced cell therapy and cardiovascular regeneration

Palas K. Chanda; Roman Sukhovershin; John P. Cooke

doi:10.3390/cells10010187

MRNA-enhanced cell therapy and cardiovascular regeneration

Palas K. Chanda, Roman Sukhovershin, John P. Cooke

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

Original language	English (US)
Article number	187
Pages (from-to)	1-13
Number of pages	13
Journal	Cells
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/cells10010187
State	Published - Jan 2021

Keywords

RNA therapeutics
cardiovascular ageing
cardiovascular regeneration
cell therapy
iPSCs
inflammatory signaling
nuclear reprogramming
transdifferentiation
Cell therapy
Nuclear reprogramming
Cardiovascular ageing
IPSCs
Transdifferentiation
Inflammatory signaling
Cardiovascular regeneration

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.3390/cells10010187

Cite this

@article{6b924b9fe67d4415b2f9ed86fd430095,

title = "MRNA-enhanced cell therapy and cardiovascular regeneration",

abstract = "mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.",

keywords = "RNA therapeutics, cardiovascular ageing, cardiovascular regeneration, cell therapy, iPSCs, inflammatory signaling, nuclear reprogramming, transdifferentiation, Cell therapy, Nuclear reprogramming, Cardiovascular ageing, IPSCs, Transdifferentiation, Inflammatory signaling, Cardiovascular regeneration",

author = "Chanda, {Palas K.} and Roman Sukhovershin and Cooke, {John P.}",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

doi = "10.3390/cells10010187",

language = "English (US)",

volume = "10",

pages = "1--13",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

TY - JOUR

T1 - MRNA-enhanced cell therapy and cardiovascular regeneration

AU - Chanda, Palas K.

AU - Sukhovershin, Roman

AU - Cooke, John P.

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

AB - mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

KW - RNA therapeutics

KW - cardiovascular ageing

KW - cardiovascular regeneration

KW - cell therapy

KW - iPSCs

KW - inflammatory signaling

KW - nuclear reprogramming

KW - transdifferentiation

KW - Cell therapy

KW - Nuclear reprogramming

KW - Cardiovascular ageing

KW - IPSCs

KW - Transdifferentiation

KW - Inflammatory signaling

KW - Cardiovascular regeneration

UR - http://www.scopus.com/inward/record.url?scp=85100327200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85100327200&partnerID=8YFLogxK

U2 - 10.3390/cells10010187

DO - 10.3390/cells10010187

M3 - Review article

C2 - 33477787

AN - SCOPUS:85100327200

SN - 2073-4409

VL - 10

SP - 1

EP - 13

JO - Cells

JF - Cells

IS - 1

M1 - 187

ER -

MRNA-enhanced cell therapy and cardiovascular regeneration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this