@article{80e2e85ebaf542ef80eccf9108fb6793,
title = "m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination",
abstract = "Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.",
keywords = "Mettl14, NF155, RNA epigenetic regulation, alternative splicing, m(6)A, mRNA methylation, myelin, oligodendrocyte development, oligodendrocyte precursor cells, oligodendrocytes, Oligodendrocyte Precursor Cells/physiology, Cell Count, Male, Cell Adhesion Molecules/metabolism, Cell Differentiation/physiology, Female, Methyltransferases/genetics, Nerve Growth Factors/metabolism, Cells, Cultured, Mice, Transgenic, Myelin Sheath/physiology, RNA, Messenger/metabolism, Cell Lineage, Adenosine/analogs & derivatives, Animals, Mice, Methylation, Oligodendroglia/cytology",
author = "Huan Xu and Yulia Dzhashiashvili and Ankeeta Shah and Kunjamma, {Rejani B.} and Weng, {Yi lan} and Benayahu Elbaz and Qili Fei and Jones, {Joshua S.} and Li, {Yang I.} and Xiaoxi Zhuang and Ming, {Guo li} and Chuan He and Brian Popko",
note = "Funding Information: This work was supported by the National Institutes of Health (NIH) , United States ( R01NS109372 to B.P., R35NS097370 to G.-l.M.), the National Multiple Sclerosis Society, United States ( PP-1603-08106 to B.P.), and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, United States to B.P. and G.-l.M. We thank the Genomics facility at the University of Chicago and the Bioinformatics core at the University of Illinois of Chicago for assistance. The Bioinformatics analysis in the project described was performed by the UIC Research Informatics Core, supported in part by National Center for Advancing Translational Sciences ( NCATS), United States, through grant UL1TR002003 . We also thank Dr. Ben Emery for generously providing MYRF antibody for this project and Dr. Vytas Bindokas, Dr. Xiaochang Zhang, Erdong Liu, Gloria Wright, and Ani Solanki for critical advice and assistance. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = jan,
day = "22",
doi = "10.1016/j.neuron.2019.12.013",
language = "English (US)",
volume = "105",
pages = "293--309.e5",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}