Abstract
Functional magnetic resonance imaging (fMRI) has complementary spatiotemporal resolution compared to Electroencephalography (EEG) as well as Magnetoencephalography (MEG). Thus, their integrated analysis should improve the overall resolution. To integrate analysis of E/MEG and fMRI, we extend our previously proposed integrated E/MEG and fMRI neural mass model to a multi-area model by defining two types of connections: the Short-Range Connections (SRCs) between minicolumns within the areas and Long-Range Connections (LRCs) between inter-areas minicolumns. The nonlinear input/output relationship in the proposed model is derived from the state space representation of the multi-area model. The E/MEG signals are originated from the overall synaptic activities of the pyramidal cells of all minicolumns and can be calculated using the lead field matrix (i.e., forward electromagnetic model). The fMRI signal is extracted from the proposed integrated model by calculating the overall neural activities in the areas and using it as the input of the extended balloon model (EBM). Using the simulation results, the capabilities of the proposed model to generate E/MEG and fMRI signals is shown. In addition, changes in the dynamics of the model to variations of its parameters were evaluated and lead us to the appropriate ranges for the parameters. In conclusion, this work proposes an effective method to integrate E/MEG and fMRI for the more effective use of these techniques in functional neuroimaging.
Original language | English (US) |
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Title of host publication | Medical Imaging 2009 |
Subtitle of host publication | Biomedical Applications in Molecular, Structural, and Functional Imaging |
Volume | 7262 |
DOIs | |
State | Published - Jun 22 2009 |
Event | Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States Duration: Feb 8 2009 → Feb 10 2009 |
Other
Other | Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging |
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Country/Territory | United States |
City | Lake Buena Vista, FL |
Period | 2/8/09 → 2/10/09 |
Keywords
- Electroencephalography (EEG)
- Functional magnetic resonance imaging (fMRI)
- Magnetoencephalography (MEG)
- Multi-area modeling
- Neural mass model
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging