@inbook{d3af9fdfea0845b4985217baa73161f3,
title = "Multiscale models for transport and biodistribution of therapeutics in cancer",
abstract = "The chapter discusses the computational framework dedicated to simulate time-dependent biodistribution with focus on cancer. While systemic pharmacokinetic and biodistribution problems are extensively studied, the factors considered here are drug transport from drug vectors, drug transport and biodistribution in the tumor microenvironment, whole organ, and including the biodistribution effect on tumor growth. Continuum-based computational strategies are presented. Selected example solutions demonstrate the applicability of this methodology to in vitro and in vivo conditions.",
keywords = "Convection, Diffusion, Doxorubicin, Finite element method, Molecular dynamics, Pharmacokinetics, Tumor microenvironment",
author = "Arturas Ziemys and Milos Kojic and Miljan Milosevic and Bernhard Schrefler and Mauro Ferrari",
note = "Funding Information: B.A.S. acknowledges the support of the Technische Universit{\"a}t M{\"u}nchen—Institute for Advanced Study, funded by the German Excellence Initiative and the European Union Seventh Framework Programme under Grant agreement no. 291763. B.A.S. further wishes to thank Pietro Mascheroni and Raffaella Santagiuliana for their collaboration. M.F. acknowledges the support from NCI U54 CA210181 and The Ernest Cockrell Jr. Presidential Distinguished Chair at Houston Methodist Research Institute. M.K. acknowledges the support from the Ministry of Education and Science of Serbia, Grants OI 174028 and III 41007, and the City of Kragujevac. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/B978-0-444-63964-6.00007-6",
language = "English (US)",
isbn = "9780444639646",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier B.V.",
pages = "209--237",
editor = "Davide Manca",
booktitle = "Computer Aided Chemical Engineering",
}