TY - JOUR
T1 - Nanobiosensing with graphene and carbon quantum dots
T2 - Recent advances
AU - Walther, Brandon K.
AU - Dinu, Cerasela Zoica
AU - Guldi, Dirk M.
AU - Sergeyev, Vladimir G.
AU - Creager, Stephen E.
AU - Cooke, John P.
AU - Guiseppi-Elie, Anthony
N1 - Funding Information:
The authors acknowledge the support of Texas Engineering Experiment Station (TEES), ABTECH Scientific, Inc. for providing access to biochip substrates and the consortium of the C3B. BKW thanks the Department of Cardiovascular Sciences for a graduate traineeship. The work of CZD is funded in part by the National Science Foundation (1454320). The work of JPC and BKW is funded in part by the National Institutes of Health ( HL133254 and HL148338 ); the George and Angelina Kostas Research Center for Cardiovascular Medicine; and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. The authors thank Chris Akers for his artistic talents in generating Figs. 1 and 2 a.
Funding Information:
The authors acknowledge the support of Texas Engineering Experiment Station (TEES), ABTECH Scientific, Inc. for providing access to biochip substrates and the consortium of the C3B. BKW thanks the Department of Cardiovascular Sciences for a graduate traineeship. The work of CZD is funded in part by the National Science Foundation (1454320). The work of JPC and BKW is funded in part by the National Institutes of Health (HL133254 and HL148338); the George and Angelina Kostas Research Center for Cardiovascular Medicine; and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. The authors thank Chris Akers for his artistic talents in generating Figs. 1 and 2a.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10
Y1 - 2020/10
N2 - Graphene and carbon quantum dots (GQDs and CQDs) are relatively new nanomaterials that have demonstrated impact in multiple different fields thanks to their unique quantum properties and excellent biocompatibility. Biosensing, analyte detection and monitoring wherein a key feature is coupled molecular recognition and signal transduction, is one such field that is being greatly advanced by the use of GQDs and CQDs. In this review, recent progress on the development of biotransducers and biosensors enabled by the creative use of GQDs and CQDs is reviewed, with special emphasis on how these materials specifically interface with biomolecules to improve overall analyte detection. This review also introduces nano-enabled biotransducers and different biosensing configurations and strategies, as well as highlights key properties of GQDs and CQDs that are pertinent to functional biotransducer design. Following relevant introductory material, the literature is surveyed with emphasis on work performed over the last 5 years. General comments and suggestions to advance the direction and potential of the field are included throughout the review. The strategic purpose is to inspire and guide future investigations into biosensor design for quality and safety, as well as serve as a primer for developing GQD- and CQD-based biosensors.
AB - Graphene and carbon quantum dots (GQDs and CQDs) are relatively new nanomaterials that have demonstrated impact in multiple different fields thanks to their unique quantum properties and excellent biocompatibility. Biosensing, analyte detection and monitoring wherein a key feature is coupled molecular recognition and signal transduction, is one such field that is being greatly advanced by the use of GQDs and CQDs. In this review, recent progress on the development of biotransducers and biosensors enabled by the creative use of GQDs and CQDs is reviewed, with special emphasis on how these materials specifically interface with biomolecules to improve overall analyte detection. This review also introduces nano-enabled biotransducers and different biosensing configurations and strategies, as well as highlights key properties of GQDs and CQDs that are pertinent to functional biotransducer design. Following relevant introductory material, the literature is surveyed with emphasis on work performed over the last 5 years. General comments and suggestions to advance the direction and potential of the field are included throughout the review. The strategic purpose is to inspire and guide future investigations into biosensor design for quality and safety, as well as serve as a primer for developing GQD- and CQD-based biosensors.
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U2 - 10.1016/j.mattod.2020.04.008
DO - 10.1016/j.mattod.2020.04.008
M3 - Review article
AN - SCOPUS:85084644291
SN - 1369-7021
VL - 39
SP - 23
EP - 46
JO - Materials Today
JF - Materials Today
ER -