TY - JOUR
T1 - Nanodelivery Systems Face Challenges and Limitations in Bone Diseases Management
AU - Giordano, Federica
AU - Lenna, Stefania
AU - Rampado, Riccardo
AU - Brozovich, Ava
AU - Hirase, Takashi
AU - Tognon, Mauro G.
AU - Martini, Fernanda
AU - Agostini, Marco
AU - Yustein, Jason T.
AU - Taraballi, Francesca
N1 - Funding Information:
This work was supported in part by the Cancer Prevention & Research Institute of Texas (Award ID RP180394) and PRIN 2017 grant 2017C8RYSS_002 from Ministero dell'Università e Ricerca, Rome, Italy (to F.M.). The authors would like to thank Amanda Weiskoff, Ph.D. (Academic Affairs, Houston Methodist Academic Institute) for scientific editing assistance. The graphical abstact image was created using Biorender.com.
Funding Information:
This work was supported in part by the Cancer Prevention & Research Institute of Texas (Award ID RP180394) and PRIN 2017 grant 2017C8RYSS_002 from Ministero dell'Università e Ricerca, Rome, Italy (to F.M.). The authors would like to thank Amanda Weiskoff, Ph.D. (Academic Affairs, Houston Methodist Academic Institute) for scientific editing assistance. The graphical abstact image was created using Biorender.com.
Publisher Copyright:
© 2021 The Authors. Advanced Therapeutics published by Wiley-VCH GmbH
PY - 2021/12
Y1 - 2021/12
N2 - Bone is a highly dynamic tissue. Hence, diseases affecting bone tissue, such as cancer (primary tumors and metastases), osteoporosis, and genetic conditions present many challenges for traditional therapies, leading to poor therapeutic outcome. Nano-delivery systems are innovative tools used for the treatment of a variety of diseases due to their ability to deliver various therapeutic cargos and specifically target disease sites, including difficult ones like bone. A variety of nano-delivery strategies are recently explored to treat bone-related pathologies, with many resulting in better outcomes than traditional approaches. In this review, the authors cover recent attempts to use nano-delivery systems for the treatment of skeletal-related disorders including primary bone tumors, metastatic bone tumors, and non-cancerous bone disorders. Finally, potential barriers for the translation of such new therapeutics into the clinic and possible methods to overcome these barriers, are discussed.
AB - Bone is a highly dynamic tissue. Hence, diseases affecting bone tissue, such as cancer (primary tumors and metastases), osteoporosis, and genetic conditions present many challenges for traditional therapies, leading to poor therapeutic outcome. Nano-delivery systems are innovative tools used for the treatment of a variety of diseases due to their ability to deliver various therapeutic cargos and specifically target disease sites, including difficult ones like bone. A variety of nano-delivery strategies are recently explored to treat bone-related pathologies, with many resulting in better outcomes than traditional approaches. In this review, the authors cover recent attempts to use nano-delivery systems for the treatment of skeletal-related disorders including primary bone tumors, metastatic bone tumors, and non-cancerous bone disorders. Finally, potential barriers for the translation of such new therapeutics into the clinic and possible methods to overcome these barriers, are discussed.
KW - bone diseases
KW - metastases
KW - nanomedicine
KW - theranostics
KW - tumor
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U2 - 10.1002/adtp.202100152
DO - 10.1002/adtp.202100152
M3 - Review article
AN - SCOPUS:85117134961
SN - 2366-3987
VL - 4
JO - advanced therapeutics
JF - advanced therapeutics
IS - 12
M1 - 2100152
ER -