TY - JOUR
T1 - Nanomaterials modulate stem cell differentiation
T2 - biological interaction and underlying mechanisms
AU - Wei, Min
AU - Li, Song
AU - Le, Weidong
N1 - Funding Information:
This work was supported by Grants from the National Natural Science Foundation of China (31400853, 81430021 and 81370470), the Program for Liaoning Innovative Research Team in University (LT2015009).
PY - 2017/10/25
Y1 - 2017/10/25
N2 - Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.
AB - Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.
KW - Differentiation
KW - Nanomaterials
KW - Stem cells
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U2 - 10.1186/s12951-017-0310-5
DO - 10.1186/s12951-017-0310-5
M3 - Review article
C2 - 29065876
AN - SCOPUS:85033552818
SN - 1477-3155
VL - 15
SP - 75
JO - Journal of Nanobiotechnology
JF - Journal of Nanobiotechnology
IS - 1
ER -