Nanotechnology for the delivery of therapeutic nucleic acids

Nucleic acid (NA) therapeutics has been extensively studied both in academia and in the pharmaceutical industry and is still considered as the promise for new therapeutic modalities especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to new therapeutic modality is the lack of efficient and safe delivery strategies. In this book, written by world experts in the field of nanotechnology for NA delivery, we bring together the state of the art in delivery strategies using lipids, polymers, chemical conjugates, NA aptamers, and proteins with strong emphasis on issues and aspects that are of essence to the pharmaceutical industry working in areas such as stability, general toxicity, immune-toxicity, pharmacokinetics, and the efficacy and validation of new drug targets in vivo by using unique approaches based on exquisite nanotechnology strategies. The contributing authors are world leaders in their respective fields and founders of different approaches. This is the first time ever that they have come together and described their strategies to overcome the delivery hurdle in a safe manner. Clear, easy to understand, and focused on key issues for future research and development, this book provides new insights into the dynamic field of NA delivery using nanotechnology.