TY - JOUR
T1 - Neurogranin
T2 - A Potential Biomarker of Neurological and Mental Diseases
AU - Xiang, Yang
AU - Xin, Jiayan
AU - Le, Weidong
AU - Yang, Yongjian
N1 - Funding Information:
This study was supported in part by the National Natural Science Foundation of China Fund (Grant No. 81601112), Sichuan Department of Science and Technology Fund (Grant No. 2018SZ0141), Top Project of Youth Incubation Program of Military Medical Science and Technology (Grant No. 19QNP065), and China’s Post-doctoral Science Fund (Grant No. 2017M623357).
Funding Information:
We are deeply appreciative of the participants in this study, and thank all staff for their support and assistance. Funding. This study was supported in part by the National Natural Science Foundation of China Fund (Grant No. 81601112), Sichuan Department of Science and Technology Fund (Grant No. 2018SZ0141), Top Project of Youth Incubation Program of Military Medical Science and Technology (Grant No. 19QNP065), and China?s Post-doctoral Science Fund (Grant No. 2017M623357).
Publisher Copyright:
© Copyright © 2020 Xiang, Xin, Le and Yang.
PY - 2020/10/6
Y1 - 2020/10/6
N2 - Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal cells of the hippocampus and cortex. However, its clinical value is not fully clear so far. Currently, Ng is proved to be involved in synaptic plasticity, synaptic regeneration, and long-term potentiation mediated by the calcium- and calmodulin-signaling pathways. Due to both the synaptic integrity and function as the growing concerns in the pathogenesis of a wide variety of neurological and mental diseases, a series of researches published focused on the associations between Ng and these kinds of diseases in the past decade. Therefore, in this review, we highlight several diseases, which include, but are not limited to, Alzheimer’s disease, Parkinson disease, Creutzfeldt–Jakob disease, neuro-HIV, neurosyphilis, schizophrenia, depression, traumatic brain injury, and acute ischemic stroke, and summarize the associations between cerebrospinal fluid or blood-derived Ng with these diseases. We propose that Ng is a potential and promising biomarker to improve the diagnosis, prognosis, and severity evaluation of these diseases in the future.
AB - Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal cells of the hippocampus and cortex. However, its clinical value is not fully clear so far. Currently, Ng is proved to be involved in synaptic plasticity, synaptic regeneration, and long-term potentiation mediated by the calcium- and calmodulin-signaling pathways. Due to both the synaptic integrity and function as the growing concerns in the pathogenesis of a wide variety of neurological and mental diseases, a series of researches published focused on the associations between Ng and these kinds of diseases in the past decade. Therefore, in this review, we highlight several diseases, which include, but are not limited to, Alzheimer’s disease, Parkinson disease, Creutzfeldt–Jakob disease, neuro-HIV, neurosyphilis, schizophrenia, depression, traumatic brain injury, and acute ischemic stroke, and summarize the associations between cerebrospinal fluid or blood-derived Ng with these diseases. We propose that Ng is a potential and promising biomarker to improve the diagnosis, prognosis, and severity evaluation of these diseases in the future.
KW - biomarker
KW - cerebrospinal fluid
KW - mental disorder
KW - neurodegenerative disorder
KW - neurogranin
UR - http://www.scopus.com/inward/record.url?scp=85093537476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85093537476&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2020.584743
DO - 10.3389/fnagi.2020.584743
M3 - Review article
C2 - 33132903
AN - SCOPUS:85093537476
SN - 1663-4365
VL - 12
SP - 584743
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 584743
ER -