TY - JOUR
T1 - New methods for nanotoxicology
T2 - Synchrotron radiation-based techniques
AU - Wang, Bing
AU - Wang, Zhe
AU - Feng, Weiyue
AU - Wang, Meng
AU - Hu, Zhongbo
AU - Chai, Zhifang
AU - Zhao, Yuliang
N1 - Funding Information:
Acknowledgements The authors are grateful to the Foundations of the MOST 973 program (2006CB705605, 2009CB930204), the CAS Knowledge Innovation Program (KJCX3.SYW.N3), and the National Natural Science Foundation of China (10975148, 10905064 and 20805048), and 973 program 2010CB933904.
PY - 2010/9
Y1 - 2010/9
N2 - Nanotoxicology, a new branch of bionanoscience, deals with the study and application of the toxic or biological effects of nanomaterials or nanostructures, and aims to fill gaps in our knowledge of interactions between nano- and biosystems. However, progress in this new discipline largely relies on developing methodology to characterize nanomaterials in biological samples, quantify nanoparticles in living systems, and study their uptake, translocation, biodistribution, location and chemical status in vitro and in vivo, etc. In this review article, we focus on the main features of synchrotron radiation-based methods and their application to the study of the toxicological activities of nanomaterials. Synchrotron radiation-based analytical techniques are shown to provide a potent means for characterizing the toxic or biological behaviors of nanoparticles in biological systems.
AB - Nanotoxicology, a new branch of bionanoscience, deals with the study and application of the toxic or biological effects of nanomaterials or nanostructures, and aims to fill gaps in our knowledge of interactions between nano- and biosystems. However, progress in this new discipline largely relies on developing methodology to characterize nanomaterials in biological samples, quantify nanoparticles in living systems, and study their uptake, translocation, biodistribution, location and chemical status in vitro and in vivo, etc. In this review article, we focus on the main features of synchrotron radiation-based methods and their application to the study of the toxicological activities of nanomaterials. Synchrotron radiation-based analytical techniques are shown to provide a potent means for characterizing the toxic or biological behaviors of nanoparticles in biological systems.
KW - Methodology
KW - Nanomaterials
KW - Nanotoxicology
KW - Synchrotron radiation techniques
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U2 - 10.1007/s00216-010-3752-2
DO - 10.1007/s00216-010-3752-2
M3 - Review article
C2 - 20526771
AN - SCOPUS:77957885479
SN - 1618-2642
VL - 398
SP - 667
EP - 676
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
IS - 2
ER -