@inproceedings{e2bf1062b4ba465cbe124af38acda8a0,
title = "New opportunities to probe microbial population genetics by lab-on-a-chip devices",
abstract = "In this work, we design and fabricate an integrated multi-level, hydrodynamically-optimized microfluidic chip to study long-term Escherichia coli population dynamics in a microfluidic device. Our experiments show that a population of proliferating E. coli in a microchannel organizes into lanes of genetically identical cells within a few generations. This behavior can be theoretically predicted to confirm that genetic diversity is quickly lost along lanes of cells. Our findings elucidate the effect of lane formation on populations evolution, with potential applications ranging from microbial ecology in soil to dynamics of epithelial tissues in higher organisms.",
keywords = "Bacteria evolution, Microbial population genetics, Microfluidics",
author = "Anzhelika Koldaeva and Tsai, {Paul Hsieh Fu} and Simone Pigolotti and Shen, {Amy Q.}",
note = "Funding Information: We gratefully acknowledge support of the Okinawa Institute of Science and Technology Graduate University (OIST) with subsidy fuing nfromdthe Cabinet Office, Government of Japan. We are grateful for the help and support provided by the Scientific Computing and Data Analysis section of Research Support Division at OIST. Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",
year = "2022",
language = "English (US)",
series = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "45--47",
booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}