Nongenomic effects of estrogen: Why all the uncertainty?

Margaret Warner; Jan Åke Gustafsson

doi:10.1016/j.steroids.2005.09.001

Nongenomic effects of estrogen: Why all the uncertainty?

Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journal › Editorial › peer-review

69 Scopus citations

Abstract

It is clear that estradiol has profound, rapid effects on the conformation of the estrogen receptors (ERs), ERα and ERβ, which mediate the transcriptional effects of estradiol. Estrogen can elicit many other rapid changes in cells including changes in ion fluxes across membranes and stimulation of kinases and phosphatases. The proteins which are the targets of these actions are the subject of intense investigation. One of the issues that have not been satisfactorily resolved is whether ERα or ERβ can reside in the plasma membrane and participate in the rapid effects of estrogen. In the present commentary, we take a careful look at some of the published data in an attempt to understand why it is so difficult to obtain a definitive answer to this question.

Original language	English (US)
Pages (from-to)	91-95
Number of pages	5
Journal	Steroids
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/j.steroids.2005.09.001
State	Published - Feb 2006

Keywords

Estrogen receptors
Nongenomic effects
Stimulation

ASJC Scopus subject areas

Biochemistry
Endocrinology
Molecular Biology

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10.1016/j.steroids.2005.09.001

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title = "Nongenomic effects of estrogen: Why all the uncertainty?",

abstract = "It is clear that estradiol has profound, rapid effects on the conformation of the estrogen receptors (ERs), ERα and ERβ, which mediate the transcriptional effects of estradiol. Estrogen can elicit many other rapid changes in cells including changes in ion fluxes across membranes and stimulation of kinases and phosphatases. The proteins which are the targets of these actions are the subject of intense investigation. One of the issues that have not been satisfactorily resolved is whether ERα or ERβ can reside in the plasma membrane and participate in the rapid effects of estrogen. In the present commentary, we take a careful look at some of the published data in an attempt to understand why it is so difficult to obtain a definitive answer to this question.",

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AB - It is clear that estradiol has profound, rapid effects on the conformation of the estrogen receptors (ERs), ERα and ERβ, which mediate the transcriptional effects of estradiol. Estrogen can elicit many other rapid changes in cells including changes in ion fluxes across membranes and stimulation of kinases and phosphatases. The proteins which are the targets of these actions are the subject of intense investigation. One of the issues that have not been satisfactorily resolved is whether ERα or ERβ can reside in the plasma membrane and participate in the rapid effects of estrogen. In the present commentary, we take a careful look at some of the published data in an attempt to understand why it is so difficult to obtain a definitive answer to this question.

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Nongenomic effects of estrogen: Why all the uncertainty?

Abstract

Keywords

ASJC Scopus subject areas

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