TY - GEN
T1 - Noninvasive functional imaging of tissue abnormalities using optical coherence tomography
AU - Larin, Kirill V.
AU - Morrisett, Joel D.
AU - Ghosn, Mohamad G.
AU - Tuchin, Valery V.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Diagnostic imaging techniques are commonly used in a clinical setting for the detection of abnormalities. Optical coherence tomography (OCT) is a relatively novel imaging technique capable of performing structural and functional analysis of various tissue specimens. When structural imaging is limited by the resolution of the system, functional imaging, e.g. through the quantification of the permeability rate of chemical compounds within tissue, can be used to distinguish between normal and abnormal tissue. In this paper we quantitatively demonstrate that the spatiotemporal diffusion characteristics of various compounds in ocular and vascular tissues assessed with OCT-based functional biosensor has superior sensitivity for the detection of early tissue abnormalities when compared to other standard imaging methods. For example, the permeability of glucose molecules in abnormal porcine aorta was found to be more than triple that in normal tissue while structural imaging failed to find the difference. These results suggest that OCT has great capability to enhance and supplement existing biosensing/diagnostic methods in the detection and assessment of tissue abnormalities.
AB - Diagnostic imaging techniques are commonly used in a clinical setting for the detection of abnormalities. Optical coherence tomography (OCT) is a relatively novel imaging technique capable of performing structural and functional analysis of various tissue specimens. When structural imaging is limited by the resolution of the system, functional imaging, e.g. through the quantification of the permeability rate of chemical compounds within tissue, can be used to distinguish between normal and abnormal tissue. In this paper we quantitatively demonstrate that the spatiotemporal diffusion characteristics of various compounds in ocular and vascular tissues assessed with OCT-based functional biosensor has superior sensitivity for the detection of early tissue abnormalities when compared to other standard imaging methods. For example, the permeability of glucose molecules in abnormal porcine aorta was found to be more than triple that in normal tissue while structural imaging failed to find the difference. These results suggest that OCT has great capability to enhance and supplement existing biosensing/diagnostic methods in the detection and assessment of tissue abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=79951916794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951916794&partnerID=8YFLogxK
U2 - 10.1109/ICSENS.2010.5690809
DO - 10.1109/ICSENS.2010.5690809
M3 - Conference contribution
AN - SCOPUS:79951916794
SN - 9781424481682
T3 - Proceedings of IEEE Sensors
SP - 2283
EP - 2286
BT - IEEE Sensors 2010 Conference, SENSORS 2010
T2 - 9th IEEE Sensors Conference 2010, SENSORS 2010
Y2 - 1 November 2010 through 4 November 2010
ER -