TY - JOUR
T1 - Novel aspects of estrogen action.
AU - Gustafsson, J. A.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2000
Y1 - 2000
N2 - The discovery of a second estrogen receptor, ER beta, in 1996 introduced a new paradigm in our understanding of estrogen action. ER alpha predominates in the uterus and mammary gland, whereas ER beta has significant roles in the central nervous, cardiovascular, and immune systems, urogenital tract, bone, kidney, and lung. ER beta appears to be the only from expressed in the embryonal central nervous system. Photoestrogens may be good candidates for physiologic ligands of ER beta. Coactivator proteins play critical roles in regulating estrogen. Female ER beta-deleted mice (beta ERKO) develop follicular arrest and anovulation.
AB - The discovery of a second estrogen receptor, ER beta, in 1996 introduced a new paradigm in our understanding of estrogen action. ER alpha predominates in the uterus and mammary gland, whereas ER beta has significant roles in the central nervous, cardiovascular, and immune systems, urogenital tract, bone, kidney, and lung. ER beta appears to be the only from expressed in the embryonal central nervous system. Photoestrogens may be good candidates for physiologic ligands of ER beta. Coactivator proteins play critical roles in regulating estrogen. Female ER beta-deleted mice (beta ERKO) develop follicular arrest and anovulation.
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U2 - 10.1177/1071557600007001s04
DO - 10.1177/1071557600007001s04
M3 - Review article
C2 - 10732321
AN - SCOPUS:17144473977
SN - 1071-5576
VL - 7
SP - S8-9
JO - Journal of the Society for Gynecologic Investigation
JF - Journal of the Society for Gynecologic Investigation
IS - 1 Suppl
ER -