Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: A pilot study

Prathap Jayaram; Gu Eon Kang; Brett L. Heldt; Olumide Sokunbi; Bo Song; Peter C. Yeh; Max Epstein; Theodore B. Shybut; Brendan H. Lee; Bijan Najafi

doi:10.2217/rme-2021-0032

Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: A pilot study

Prathap Jayaram, Gu Eon Kang, Brett L. Heldt, Olumide Sokunbi, Bo Song, Peter C. Yeh, Max Epstein, Theodore B. Shybut, Brendan H. Lee, Bijan Najafi

Houston Methodist

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.

Original language	English (US)
Pages (from-to)	823-832
Number of pages	10
Journal	Regenerative Medicine
Volume	16
Issue number	9
DOIs	https://doi.org/10.2217/rme-2021-0032
State	Published - Sep 2021

Keywords

balance
functional outcomes
gait
knee injury and osteoarthritis outcome score 12
knee osteoarthritis
leukocyte-rich platelet-rich plasma
patient-reported outcomes
timed up and go
wearable sensor technology

ASJC Scopus subject areas

Biomedical Engineering
Embryology

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10.2217/rme-2021-0032

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@article{fa12265bab5343569ee59ed17d91e600,

title = "Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: A pilot study",

abstract = "Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.",

keywords = "balance, functional outcomes, gait, knee injury and osteoarthritis outcome score 12, knee osteoarthritis, leukocyte-rich platelet-rich plasma, patient-reported outcomes, timed up and go, wearable sensor technology",

author = "Prathap Jayaram and Kang, {Gu Eon} and Heldt, {Brett L.} and Olumide Sokunbi and Bo Song and Yeh, {Peter C.} and Max Epstein and Shybut, {Theodore B.} and Lee, {Brendan H.} and Bijan Najafi",

note = "Funding Information: This research was funded, in part, by the National Heart, Lung and Blood Institute (grant number: 5T32HL139430-02) and by the National Institute on Aging (grant number: 1R42AG060853-01). P Jayaram was supported by the HAE AHM Sea Rock Foundation and the Charlotte and Jamil Azzam Foundation. B Najafi and GE Kang have NIH funding (grant numbers: 1R42AG060853-01 and 5T32HL139430-02, respectively). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Future Medicine Ltd.. All rights reserved.",

year = "2021",

month = sep,

doi = "10.2217/rme-2021-0032",

language = "English (US)",

volume = "16",

pages = "823--832",

journal = "Regenerative Medicine",

issn = "1746-0751",

publisher = "Future Medicine Ltd.",

number = "9",

}

TY - JOUR

T1 - Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis

T2 - A pilot study

AU - Jayaram, Prathap

AU - Kang, Gu Eon

AU - Heldt, Brett L.

AU - Sokunbi, Olumide

AU - Song, Bo

AU - Yeh, Peter C.

AU - Epstein, Max

AU - Shybut, Theodore B.

AU - Lee, Brendan H.

AU - Najafi, Bijan

N1 - Funding Information: This research was funded, in part, by the National Heart, Lung and Blood Institute (grant number: 5T32HL139430-02) and by the National Institute on Aging (grant number: 1R42AG060853-01). P Jayaram was supported by the HAE AHM Sea Rock Foundation and the Charlotte and Jamil Azzam Foundation. B Najafi and GE Kang have NIH funding (grant numbers: 1R42AG060853-01 and 5T32HL139430-02, respectively). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2021 Future Medicine Ltd.. All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.

AB - Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.

KW - balance

KW - functional outcomes

KW - gait

KW - knee injury and osteoarthritis outcome score 12

KW - knee osteoarthritis

KW - leukocyte-rich platelet-rich plasma

KW - patient-reported outcomes

KW - timed up and go

KW - wearable sensor technology

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AN - SCOPUS:85115055315

SN - 1746-0751

VL - 16

SP - 823

EP - 832

JO - Regenerative Medicine

JF - Regenerative Medicine

IS - 9

ER -

Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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