Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice

Claes Ohlsson; Nina Hellberg; Paolo Parini; Olle Vidal; Mohammed Bohlooly; Mats Rudling; Marie K. Lindberg; Margaret Warner; Bo Angelin; Jan Åke Gustafsson

doi:10.1006/bbrc.2000.3827

Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice

Claes Ohlsson, Nina Hellberg, Paolo Parini, Olle Vidal, Mohammed Bohlooly, Mats Rudling, Marie K. Lindberg, Margaret Warner, Bo Angelin, Jan Åke Gustafsson

Research output: Contribution to journal › Article › peer-review

289 Scopus citations

Abstract

Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERα knockout (ERKO), ERβ knockout (BERKO), and ERα/β double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERα but not ERβ-inactivated male mice develop obesity after sexual maturation. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	640-645
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	278
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.2000.3827
State	Published - Nov 30 2000

Keywords

Cholesterol
Dual energy X-ray absorptiometry
Leptin
Lipoprotein profile
Transgenic

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1006/bbrc.2000.3827

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title = "Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice",

abstract = "Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERα knockout (ERKO), ERβ knockout (BERKO), and ERα/β double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERα but not ERβ-inactivated male mice develop obesity after sexual maturation. (C) 2000 Academic Press.",

keywords = "Cholesterol, Dual energy X-ray absorptiometry, Leptin, Lipoprotein profile, Transgenic",

author = "Claes Ohlsson and Nina Hellberg and Paolo Parini and Olle Vidal and Mohammed Bohlooly and Mats Rudling and Lindberg, {Marie K.} and Margaret Warner and Bo Angelin and Gustafsson, {Jan {\AA}ke}",

note = "Funding Information: This study was supported by the Swedish Medical Research Council, the Swedish Foundation for Strategic Research, the Bergvall Foundation, the Lundberg Foundation, the Swedish Medical Society, Pharmacia-Upjohn, Novo Nordisk Foundation, the Swedish Heart– Lung Foundation, the Swedish Association Against Rheumatic Disease, the Swedish Cancer Foundation, and Karo Bio AB. Excellent technical assistance was provided by Maud Pettersson and Lotta Uggla at the Department of Clinical Pharmacology, University of Gothenburg, Sweden.",

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AU - Ohlsson, Claes

AU - Hellberg, Nina

AU - Parini, Paolo

AU - Vidal, Olle

AU - Bohlooly, Mohammed

AU - Rudling, Mats

AU - Lindberg, Marie K.

AU - Warner, Margaret

AU - Angelin, Bo

AU - Gustafsson, Jan Åke

N1 - Funding Information: This study was supported by the Swedish Medical Research Council, the Swedish Foundation for Strategic Research, the Bergvall Foundation, the Lundberg Foundation, the Swedish Medical Society, Pharmacia-Upjohn, Novo Nordisk Foundation, the Swedish Heart– Lung Foundation, the Swedish Association Against Rheumatic Disease, the Swedish Cancer Foundation, and Karo Bio AB. Excellent technical assistance was provided by Maud Pettersson and Lotta Uggla at the Department of Clinical Pharmacology, University of Gothenburg, Sweden.

PY - 2000/11/30

Y1 - 2000/11/30

N2 - Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERα knockout (ERKO), ERβ knockout (BERKO), and ERα/β double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERα but not ERβ-inactivated male mice develop obesity after sexual maturation. (C) 2000 Academic Press.

AB - Clinical case reports have documented disturbances of carbohydrate and lipid metabolism in aromatase deficient and estrogen resistant males. The aim of the present study was to explore the metabolic functions of estrogens in male mice and to dissect the estrogen receptor (ER) specificity of such effects. Total body fat content and serum levels of leptin were followed in ERα knockout (ERKO), ERβ knockout (BERKO), and ERα/β double knockout (DERKO) mice. Neither the total body fat nor serum leptin levels were altered in any group before or during sexual maturation. However, after sexual maturation ERKO and DERKO, but not BERKO, demonstrated a clear increase in total body fat and enhanced serum leptin levels. Serum cholesterol was increased and a qualitative change in the lipoprotein profile, including smaller LDL particles, was observed in ERKO and DERKO mice. In conclusion, ERα but not ERβ-inactivated male mice develop obesity after sexual maturation. (C) 2000 Academic Press.

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Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice

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Keywords

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