TY - CHAP
T1 - Of model hosts and man
T2 - Using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as model hosts for infectious disease research
AU - Glavis-Bloom, Justin
AU - Muhammed, Maged
AU - Mylonakis, Eleftherios
PY - 2012
Y1 - 2012
N2 - The use of invertebrate model hosts has increased in popularity due to numerous advantages of invertebrates over mammalian models, including ethical, logistical and budgetary features. This review provides an introduction to three model hosts, the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and the larvae of Galleria mellonella, the greater wax moth. It highlights principal experimental advantages of each model, for C. elegans the ability to run high-throughput assays, for D. melanogaster the evolutionarily conserved innate immune response, and for G. mellonella the ability to conduct experiments at 37°C and easily inoculate a precise quantity of pathogen. It additionally discusses recent research that has been conducted with each host to identify pathogen virulence factors, study the immune response, and evaluate potential antimicrobial compounds, focusing principally on fungal pathogens.
AB - The use of invertebrate model hosts has increased in popularity due to numerous advantages of invertebrates over mammalian models, including ethical, logistical and budgetary features. This review provides an introduction to three model hosts, the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and the larvae of Galleria mellonella, the greater wax moth. It highlights principal experimental advantages of each model, for C. elegans the ability to run high-throughput assays, for D. melanogaster the evolutionarily conserved innate immune response, and for G. mellonella the ability to conduct experiments at 37°C and easily inoculate a precise quantity of pathogen. It additionally discusses recent research that has been conducted with each host to identify pathogen virulence factors, study the immune response, and evaluate potential antimicrobial compounds, focusing principally on fungal pathogens.
UR - http://www.scopus.com/inward/record.url?scp=84555188797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84555188797&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-5638-5_2
DO - 10.1007/978-1-4419-5638-5_2
M3 - Chapter
C2 - 22127881
AN - SCOPUS:84555188797
SN - 9781441956378
T3 - Advances in Experimental Medicine and Biology
SP - 11
EP - 17
BT - Recent Advances on Model Hosts
A2 - Mylonakis, Eleftherios
A2 - Ausubel, Frederick
A2 - Gilmore, Michael
A2 - Casadevall, Arturo
ER -