TY - JOUR
T1 - Olfactory Function in SCA10
AU - Moscovich, Mariana
AU - Munhoz, Renato Puppi
AU - Moro, Adriana
AU - Raskin, Salmo
AU - McFarland, Karen
AU - Ashizawa, Tetsuo
AU - Teive, Helio A.G.
AU - Silveira-Moriyama, Laura
N1 - Funding Information:
Conflict of Interest Dr. Moscovich, Dr. Munhoz, Dr. Moro, Dr. Raskin, and Dr. McFarland report no disclosure. Dr. Ashizawa is funded by NIH grant NS083564. Teive received personal compensation for educational activities with Allergan, Ipsen, Teva, and UCB and serves as an editor-in-chief of Arquivos de Neuro-Psiquiatria and editorial board member of Movement Disorder Clinical Practice, the Journal of Neurology Research, Parkinson’s Disease, Current Neurology and Neuroscience Reports, and Arquivos de Neuropsiquiatria. Dr. Laura Silveira-Moriyama received travel grants from Teva and supervised scholarships from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson’s, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson’s disease (PD)) and 44 healthy controls using the Sniffin’ Sticks (SS16) test. Mean SS16 score was 11.9 ± 2.9 for the SCA10 group, 12.3 ± 1.9 for the SCA3 group, 6.6 ± 2.8 for the PD group, and 12.1 ± 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p < 0.001) when adjusted for age, gender, and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups or number of repeat expansions. SS16 and Mini Mental State Examination scores were correlated in the three groups: SCA10 group (r = 0.59, p = 0.001), SCA3 group (r = 0.50, p = 0.005), and control group (r = 0.40, p = 0.007). We found no significant olfactory deficits in SCA10 in this large series.
AB - Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson’s, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson’s disease (PD)) and 44 healthy controls using the Sniffin’ Sticks (SS16) test. Mean SS16 score was 11.9 ± 2.9 for the SCA10 group, 12.3 ± 1.9 for the SCA3 group, 6.6 ± 2.8 for the PD group, and 12.1 ± 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p < 0.001) when adjusted for age, gender, and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups or number of repeat expansions. SS16 and Mini Mental State Examination scores were correlated in the three groups: SCA10 group (r = 0.59, p = 0.001), SCA3 group (r = 0.50, p = 0.005), and control group (r = 0.40, p = 0.007). We found no significant olfactory deficits in SCA10 in this large series.
KW - Cerebellar degeneration
KW - Movement disorders
KW - Olfaction
KW - Smell
KW - Spinocerebellar ataxia
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UR - http://www.scopus.com/inward/citedby.url?scp=85048829592&partnerID=8YFLogxK
U2 - 10.1007/s12311-018-0954-1
DO - 10.1007/s12311-018-0954-1
M3 - Article
C2 - 29922950
AN - SCOPUS:85048829592
SN - 1473-4222
VL - 18
SP - 85
EP - 90
JO - Cerebellum
JF - Cerebellum
IS - 1
ER -