Oligonucleotide aptamers for pathogen detection and infectious disease control

Quanyuan Wan; Xiaohui Liu; Youli Zu

doi:10.7150/thno.61804

Oligonucleotide aptamers for pathogen detection and infectious disease control

Quanyuan Wan, Xiaohui Liu, Youli Zu

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.

Original language	English (US)
Pages (from-to)	9133-9161
Number of pages	29
Journal	Theranostics
Volume	11
Issue number	18
DOIs	https://doi.org/10.7150/thno.61804
State	Published - 2021

Keywords

Aptamers
Aptasensors
Disease control
Immune system
Pathogen detection

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Access to Document

10.7150/thno.61804

Cite this

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abstract = "During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.",

keywords = "Aptamers, Aptasensors, Disease control, Immune system, Pathogen detection",

author = "Quanyuan Wan and Xiaohui Liu and Youli Zu",

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T1 - Oligonucleotide aptamers for pathogen detection and infectious disease control

AU - Wan, Quanyuan

AU - Liu, Xiaohui

AU - Zu, Youli

N1 - Funding Information: This project was partially supported by an NIH grant R01CA224304 and Department seed fund to Y.Z. We would like to thank Drs. Sasha Pejerrey and Heather McConnell for their scientific editing of the manuscript. Publisher Copyright: © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License

PY - 2021

Y1 - 2021

N2 - During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.

AB - During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.

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KW - Immune system

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Oligonucleotide aptamers for pathogen detection and infectious disease control

Abstract

Keywords

ASJC Scopus subject areas

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