TY - JOUR
T1 - Optimizing drug regimens and supplementation in orthognathic surgery
T2 - A comprehensive and practical guide
AU - Grillo, Ricardo
AU - Reis, Bruno Alvarez Quinta
AU - Brozoski, Mariana Aparecida
AU - Traina, Andreia Aparecida
AU - Melhem-Elias, Fernando
N1 - Funding Information:
This article was not supported by any grant.
Publisher Copyright:
© 2023 Elsevier Masson SAS
PY - 2024/2
Y1 - 2024/2
N2 - Objective: This study aimed to comprehensively review the literature and provide a practical guide for optimizing drug regimens and supplementation related to orthognathic surgery. Methods: The authors conducted a thorough review of the existing literature, following the PRISMA-ScR guidelines. Various types of studies except case reports and reviews were included. The study applied specific inclusion criteria, focusing on perioperative and/or postoperative drugs, medications, or supplementation related to orthognathic surgery. Results: This guide included 78 studies on various medications in orthognathic surgery. It encompasses clinical trials, cohort studies, cross-sectional studies, prospective and retrospective studies. The topics covered include antibiotics, analgesics, corticosteroids, antiemetics, hemostatic agents, local anesthetics, herbal medicine, and botulinum toxin. Pain and edema control involved specific medications, while local anesthesia utilized ropivacaine and bupivacaine. The guide also discusses mineral and vitamin supplementation. The effectiveness of hemostatic agents and antiemetics was highlighted. Conclusion: Pain management, reduced swelling, enhanced wound healing, and faster recovery are among the advantages. In addition to the standard drugs and medications, the inclusion of vitamin and mineral supplements, tranexamic acid, postoperative anesthetic blocks, and preemptive antiemetics is anticipated to offer various benefits in orthognathic surgery, despite the limited available evidence.
AB - Objective: This study aimed to comprehensively review the literature and provide a practical guide for optimizing drug regimens and supplementation related to orthognathic surgery. Methods: The authors conducted a thorough review of the existing literature, following the PRISMA-ScR guidelines. Various types of studies except case reports and reviews were included. The study applied specific inclusion criteria, focusing on perioperative and/or postoperative drugs, medications, or supplementation related to orthognathic surgery. Results: This guide included 78 studies on various medications in orthognathic surgery. It encompasses clinical trials, cohort studies, cross-sectional studies, prospective and retrospective studies. The topics covered include antibiotics, analgesics, corticosteroids, antiemetics, hemostatic agents, local anesthetics, herbal medicine, and botulinum toxin. Pain and edema control involved specific medications, while local anesthesia utilized ropivacaine and bupivacaine. The guide also discusses mineral and vitamin supplementation. The effectiveness of hemostatic agents and antiemetics was highlighted. Conclusion: Pain management, reduced swelling, enhanced wound healing, and faster recovery are among the advantages. In addition to the standard drugs and medications, the inclusion of vitamin and mineral supplements, tranexamic acid, postoperative anesthetic blocks, and preemptive antiemetics is anticipated to offer various benefits in orthognathic surgery, despite the limited available evidence.
KW - Analgesics
KW - Antibiotic Prophylaxis
KW - Complications
KW - Dietary Supplements
KW - Mandible
KW - Maxilla
KW - Orthognathic Surgery
KW - Orthognathic Surgical Procedures
KW - Osteotomy, Le Fort
KW - Osteotomy, Sagittal Split Ramus
KW - Postoperative
KW - Treatment Outcome
UR - http://www.scopus.com/inward/record.url?scp=85179477693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85179477693&partnerID=8YFLogxK
U2 - 10.1016/j.jormas.2023.101639
DO - 10.1016/j.jormas.2023.101639
M3 - Short survey
C2 - 37729964
AN - SCOPUS:85179477693
SN - 2468-7855
VL - 125
JO - Journal of Stomatology, Oral and Maxillofacial Surgery
JF - Journal of Stomatology, Oral and Maxillofacial Surgery
IS - 1
M1 - 101639
ER -