TY - JOUR
T1 - PARs for the course
T2 - Roles of proteases and PAR receptors in subtly inflamed irritable bowel syndrome
AU - Quigley, Eamonn Martin
PY - 2013/10
Y1 - 2013/10
N2 - Although the etiology of irritable bowel syndrome (IBS) remains unknown, clinical and laboratory observations suggest that within the broad and varying phenotype, that is, IBS, there may exist subgroups, which can be defined on the basis of a distinctive pathophysiological basis. Of these, postinfectious IBS is the best characterized; in IBS, in general, studies of inflammatory mediators and substances elaborated by cells involved in the intestinal immune response, such as proteases, suggest that some IBS sufferers can be differentiated on the basis of an aberrant immune response. Valdez-Morales and colleagues extend this concept by demonstrating the ability of supernatants of biopsy cultures from individuals with diarrhea-predominant IBS to enhance neuronal excitability - an effect that could well contribute to a clinical hallmark of IBS, namely, visceral hypersensitivity.
AB - Although the etiology of irritable bowel syndrome (IBS) remains unknown, clinical and laboratory observations suggest that within the broad and varying phenotype, that is, IBS, there may exist subgroups, which can be defined on the basis of a distinctive pathophysiological basis. Of these, postinfectious IBS is the best characterized; in IBS, in general, studies of inflammatory mediators and substances elaborated by cells involved in the intestinal immune response, such as proteases, suggest that some IBS sufferers can be differentiated on the basis of an aberrant immune response. Valdez-Morales and colleagues extend this concept by demonstrating the ability of supernatants of biopsy cultures from individuals with diarrhea-predominant IBS to enhance neuronal excitability - an effect that could well contribute to a clinical hallmark of IBS, namely, visceral hypersensitivity.
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U2 - 10.1038/ajg.2013.245
DO - 10.1038/ajg.2013.245
M3 - Review article
C2 - 24091507
AN - SCOPUS:84885454309
SN - 0002-9270
VL - 108
SP - 1644
EP - 1646
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 10
ER -