TY - JOUR
T1 - Pathogenesis of labyrinthitis associated with haemophilus influenza type b meningitis in infant rats
AU - Wiedermann, Bernhard L.
AU - Hawkins, Edith P.
AU - Johnson, Gail S.
AU - Lamberth, Linda B.
AU - Mason, Edward
AU - Kaplan, Sheldon
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The pathogenesis of labyrinthitis associated with bacterial meningitis was studied by histopathologic examination of inner ears of 114 rats with Haemophilus influenzae type b meningitis produced by ip inoculation of one of 13 clinical isolates. Findings consisted of inflammation of the perilymphatic spaces of the cochlea and semicircular canals with sparing of the endolymphatic space, cochlear nerve fibers, and middle ear. The degree of inflammation peaked at 48 hr after inoculation, then declined by 96 to 144 hr. No interstrain differences in type or degree of pathology were observed. Immunofluorescent staining of cochleae from 15 animals demonstrated that bacteria were present in areas of inflammation and also in the endolymphatic space and organ of Corti. One isolate displayed a tendency to accumulate in the perilymphatic spaces in larger numbers than those seen with three other isolates. These findings suggest that, in this model, inflammation reaches the inner ear by spreading from the subarachnoid place. Bacterial invasion of the organ of Corti may be one mechanism by which deafness occurs in bacterial meningitis.
AB - The pathogenesis of labyrinthitis associated with bacterial meningitis was studied by histopathologic examination of inner ears of 114 rats with Haemophilus influenzae type b meningitis produced by ip inoculation of one of 13 clinical isolates. Findings consisted of inflammation of the perilymphatic spaces of the cochlea and semicircular canals with sparing of the endolymphatic space, cochlear nerve fibers, and middle ear. The degree of inflammation peaked at 48 hr after inoculation, then declined by 96 to 144 hr. No interstrain differences in type or degree of pathology were observed. Immunofluorescent staining of cochleae from 15 animals demonstrated that bacteria were present in areas of inflammation and also in the endolymphatic space and organ of Corti. One isolate displayed a tendency to accumulate in the perilymphatic spaces in larger numbers than those seen with three other isolates. These findings suggest that, in this model, inflammation reaches the inner ear by spreading from the subarachnoid place. Bacterial invasion of the organ of Corti may be one mechanism by which deafness occurs in bacterial meningitis.
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U2 - 10.1093/infdis/153.1.27
DO - 10.1093/infdis/153.1.27
M3 - Article
C2 - 3510260
AN - SCOPUS:0022643311
SN - 0022-1899
VL - 153
SP - 27
EP - 32
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -