Pathophysiology of Acute and Chronic Right Heart Failure

Rajarajan A. Thandavarayan; Kalyan R. Chitturi; Ashrith Guha

doi:10.1016/j.ccl.2020.01.009

Pathophysiology of Acute and Chronic Right Heart Failure

Rajarajan A. Thandavarayan, Kalyan R. Chitturi, Ashrith Guha

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.

Original language	English (US)
Pages (from-to)	149-160
Number of pages	12
Journal	Cardiology Clinics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ccl.2020.01.009
State	Published - May 2020

Keywords

Angiogenesis
Hypertrophy
Inflammation
Mechanical circulatory support
Metabolism
Pulmonary hypertension
Right heart failure
Ventricular Dysfunction, Right/complications
Acute Disease
Ventricular Function, Right/physiology
Heart Ventricles/physiopathology
Humans
Disease Progression
Heart Failure/etiology
Myocardial Contraction/physiology

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ccl.2020.01.009

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title = "Pathophysiology of Acute and Chronic Right Heart Failure",

abstract = "Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.",

keywords = "Angiogenesis, Hypertrophy, Inflammation, Mechanical circulatory support, Metabolism, Pulmonary hypertension, Right heart failure, Ventricular Dysfunction, Right/complications, Acute Disease, Ventricular Function, Right/physiology, Heart Ventricles/physiopathology, Humans, Disease Progression, Heart Failure/etiology, Myocardial Contraction/physiology",

author = "Thandavarayan, {Rajarajan A.} and Chitturi, {Kalyan R.} and Ashrith Guha",

year = "2020",

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language = "English (US)",

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pages = "149--160",

journal = "Cardiology Clinics",

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publisher = "W.B. Saunders Ltd",

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T1 - Pathophysiology of Acute and Chronic Right Heart Failure

AU - Thandavarayan, Rajarajan A.

AU - Chitturi, Kalyan R.

AU - Guha, Ashrith

PY - 2020/5

Y1 - 2020/5

N2 - Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.

AB - Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.

KW - Angiogenesis

KW - Hypertrophy

KW - Inflammation

KW - Mechanical circulatory support

KW - Metabolism

KW - Pulmonary hypertension

KW - Right heart failure

KW - Ventricular Dysfunction, Right/complications

KW - Acute Disease

KW - Ventricular Function, Right/physiology

KW - Heart Ventricles/physiopathology

KW - Humans

KW - Disease Progression

KW - Heart Failure/etiology

KW - Myocardial Contraction/physiology

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DO - 10.1016/j.ccl.2020.01.009

M3 - Review article

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AN - SCOPUS:85081009248

SN - 0733-8651

VL - 38

SP - 149

EP - 160

JO - Cardiology Clinics

JF - Cardiology Clinics

IS - 2

ER -

Pathophysiology of Acute and Chronic Right Heart Failure

Abstract

Keywords

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