TY - GEN
T1 - Personalized drug testing of tumor samples using a microfluidic platform
AU - Rodríguez, Adán D.
AU - Horowitz, Lisa
AU - Rumaner, Maxwell
AU - Gadi, Vijayakrishna K.
AU - Monnat, Raymond
AU - Rostomily, Robert C.
AU - Folch, Albert
N1 - Funding Information:
This research was partially supported by the National Institutes of Health (Grant number: 5R01CA181445).
Publisher Copyright:
© 17CBMS-0001.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - This manuscript reports a user-friendly microfluidic platform for parallel chemosensitivity testing of live patient tissue, which we refer to as Oncoslice [1]. Oncoslice would identify a subset of therapies with the greatest potential for individual patients in a time frame appropriate for therapeutic decision-making and personalized medicine. Here we present a redesigned architecture of Oncoslice and new manufacturing techniques that will facilitate its fabrication on the larger scale necessary for clinical use. We extend our prior studies with normal mouse tissues to include testing with patient-derived glioma xenografts and clinical breast cancer biopsy samples.
AB - This manuscript reports a user-friendly microfluidic platform for parallel chemosensitivity testing of live patient tissue, which we refer to as Oncoslice [1]. Oncoslice would identify a subset of therapies with the greatest potential for individual patients in a time frame appropriate for therapeutic decision-making and personalized medicine. Here we present a redesigned architecture of Oncoslice and new manufacturing techniques that will facilitate its fabrication on the larger scale necessary for clinical use. We extend our prior studies with normal mouse tissues to include testing with patient-derived glioma xenografts and clinical breast cancer biopsy samples.
KW - Cancer Therapeutics
KW - Personalized Medicine
KW - Translational Medicine
UR - http://www.scopus.com/inward/record.url?scp=85079652116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079652116&partnerID=8YFLogxK
M3 - Conference contribution
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 235
EP - 236
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -