Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

Jinjian Hu; Wencheng Xia; Shuyi Zeng; Yeh Jun Lim; Youqi Tao; Yunpeng Sun; Lang Zhao; Haosen Wang; Weidong Le; Dan Li; Shengnan Zhang; Cong Liu; Yan Mei Li

doi:10.1038/s41467-024-46898-1

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

Jinjian Hu, Wencheng Xia, Shuyi Zeng, Yeh Jun Lim, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu, Yan Mei Li

Research output: Contribution to journal › Article › peer-review

Abstract

Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

Original language	English (US)
Article number	2677
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-46898-1
State	Published - Dec 2024

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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10.1038/s41467-024-46898-1

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title = "Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures",

abstract = "Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.",

author = "Jinjian Hu and Wencheng Xia and Shuyi Zeng and Lim, {Yeh Jun} and Youqi Tao and Yunpeng Sun and Lang Zhao and Haosen Wang and Weidong Le and Dan Li and Shengnan Zhang and Cong Liu and Li, {Yan Mei}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

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doi = "10.1038/s41467-024-46898-1",

language = "English (US)",

volume = "15",

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T1 - Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

AU - Hu, Jinjian

AU - Xia, Wencheng

AU - Zeng, Shuyi

AU - Lim, Yeh Jun

AU - Tao, Youqi

AU - Sun, Yunpeng

AU - Zhao, Lang

AU - Wang, Haosen

AU - Le, Weidong

AU - Li, Dan

AU - Zhang, Shengnan

AU - Liu, Cong

AU - Li, Yan Mei

PY - 2024/12

Y1 - 2024/12

N2 - Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

AB - Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

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U2 - 10.1038/s41467-024-46898-1

DO - 10.1038/s41467-024-46898-1

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AN - SCOPUS:85188928617

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

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M1 - 2677

ER -

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

Abstract

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