TY - JOUR
T1 - Platelet-rich plasma
T2 - a biomimetic approach to enhancement of surgical wound healing
AU - Fernandez-Moure, Joseph S.
AU - Van Eps, Jeffrey L.
AU - Cabrera, Fernando J.
AU - Barbosa, Zonia
AU - Medrano del Rosal, Guillermo
AU - Weiner, Bradley K.
AU - Ellsworth, Warren A.
AU - Tasciotti, Ennio
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.
AB - Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.
KW - Healing
KW - Infection
KW - Musculoskeletal
KW - Neovascularization
KW - Platelet-rich plasma
KW - Wound
UR - http://www.scopus.com/inward/record.url?scp=84991640213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991640213&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2016.08.063
DO - 10.1016/j.jss.2016.08.063
M3 - Article
C2 - 27979486
AN - SCOPUS:84991640213
SN - 0022-4804
VL - 207
SP - 33
EP - 44
JO - Journal of Surgical Research
JF - Journal of Surgical Research
ER -