Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter; Jacqueline Elsom; Peter P. Wibroe; S. Moein Moghimi

doi:10.1016/j.nano.2012.07.005

Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter, Jacqueline Elsom, Peter P. Wibroe, S. Moein Moghimi

Research Institute

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

Original language	English (US)
Pages (from-to)	S5-S20
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	8
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.nano.2012.07.005
State	Published - Sep 2012

Keywords

Complement
Enterocyte
Gastrointestinal tract
Microparticle
Nanoparticle
Oral drug delivery
Peyers's patch
Polymer

ASJC Scopus subject areas

Molecular Medicine
Bioengineering
Biomedical Engineering
Materials Science(all)
Medicine (miscellaneous)
Pharmaceutical Science

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10.1016/j.nano.2012.07.005

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abstract = "The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.",

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AU - Moghimi, S. Moein

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AB - The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

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KW - Enterocyte

KW - Gastrointestinal tract

KW - Microparticle

KW - Nanoparticle

KW - Oral drug delivery

KW - Peyers's patch

KW - Polymer

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Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

Abstract

Keywords

ASJC Scopus subject areas

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