Portrait of an immunoregulatory bifidobacterium

Patrycja Konieczna; Cezmi A. Akdis; Eamonn M.M. Quigley; Fergus Shanahan; Liam O'Mahony

doi:10.4161/gmic.20358

Portrait of an immunoregulatory bifidobacterium

Patrycja Konieczna, Cezmi A. Akdis, Eamonn M.M. Quigley, Fergus Shanahan, Liam O'Mahony

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

There is increasing interest in the administration of microbes or microbial metabolites for the prevention and treatment of aberrant inflammatory activity. The protective effects associated with these microbes are mediated by multiple mechanisms involving epithelial cells, DCs and T cells, but most data are derived from animal models. In this addendum, we summarize our recent data, showing that oral consumption of Bifidobacterium infantis 35624 is associated with enhanced IL-10 secretion and Foxp3 expression in human peripheral blood. In addition, we discuss the potential DC subset-specific mechanisms, which could contribute to DC_REG and T_REG programming by specific gutmicrobes.

Original language	English (US)
Pages (from-to)	261-266
Number of pages	6
Journal	Gut Microbes
Volume	3
Issue number	3
DOIs	https://doi.org/10.4161/gmic.20358
State	Published - 2012

ASJC Scopus subject areas

Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases

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10.4161/gmic.20358

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AU - O'Mahony, Liam

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Portrait of an immunoregulatory bifidobacterium

Abstract

ASJC Scopus subject areas

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