TY - JOUR
T1 - Pouteria sapota (Red Mamey Fruit)
T2 - Chemistry and Biological Activity of Carotenoids
AU - Lakey-Beitia, Johant
AU - Vasquez, Velmarini
AU - Mojica-Flores, Randy
AU - Fuentes C., Arelys L.
AU - Murillo, Enrique
AU - Hegde, Muralidhar L.
AU - Rao, K. S.
N1 - Funding Information:
This research was funded by National Secretariat for Science, Technology, and Innovation of Panama (SENACYT) grant number [GC2018-10] and SNI grants (KR, JL, VV), INDICASAT AIP Internal grant number [JR04-2020], Ministry of Economy and Finance grant number (DIPRENA-DPIP-10866-2013) on Nutritive Supplements, JL-B and K.S.R. thank SENACYT for their grant for capacity development and the Melo Brain Grant (Panama). M.L.H. is supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Ageing (NIA) of the National Institutes of Health (NIH) (award numbers R01NS088645, RF1NS112719, R03AG064266), R01NS094535, and Houston Methodist Research Institute funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
Publisher Copyright:
© 2022 Bentham Science Publishers.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
PY - 2022/7
Y1 - 2022/7
N2 - Background: Red mamey is the fruit of P. sapota, a tree found in Mesoamerica and Asia. This fruit is considered a nutraceutical due to its multiple beneficial health including antiamyloidogenic activity and potential anti-tumorigenic property. Red mamey contain a variety of carotenoids including novel ketocarotenoids such as sapotexanthin and cryptocapsin. A ketocarotenoid is a chemical compound with a carbonyl group present in the β-ring or in the double bond chain of a carotenoid. In red mamey, the 3'-deoxy-k-end group in sapotexanthin has proven to be an important pro-vitamin A source, which is essential for maintaining a healthy vision and cognitive processes. Objective: This work reviews the current knowledge about the chemistry and biological activities of carotenoids in red mamey. Method: An exhaustive extraction is the most usual methodology to isolate and thoroughly characterize the carotenoids present in this fruit. High performance liquid chromatography is used to determine the profile of total carotenoids and its purity, while atmospheric pressure chemical ionization was used to determine their molecular weight and nuclear magnetic resonance determined their structure. Result: For each 100 g of fresh weight, 0.12 mg of total carotenoid from this fruit can be obtained. Out of the more than 47 reported carotenoids in red mamey, only 34 have a detailed characterization. Conclusion: It is important to continue studying the chemical composition and biological activity of this unique tropical fruit with commercial and nutritional value.
AB - Background: Red mamey is the fruit of P. sapota, a tree found in Mesoamerica and Asia. This fruit is considered a nutraceutical due to its multiple beneficial health including antiamyloidogenic activity and potential anti-tumorigenic property. Red mamey contain a variety of carotenoids including novel ketocarotenoids such as sapotexanthin and cryptocapsin. A ketocarotenoid is a chemical compound with a carbonyl group present in the β-ring or in the double bond chain of a carotenoid. In red mamey, the 3'-deoxy-k-end group in sapotexanthin has proven to be an important pro-vitamin A source, which is essential for maintaining a healthy vision and cognitive processes. Objective: This work reviews the current knowledge about the chemistry and biological activities of carotenoids in red mamey. Method: An exhaustive extraction is the most usual methodology to isolate and thoroughly characterize the carotenoids present in this fruit. High performance liquid chromatography is used to determine the profile of total carotenoids and its purity, while atmospheric pressure chemical ionization was used to determine their molecular weight and nuclear magnetic resonance determined their structure. Result: For each 100 g of fresh weight, 0.12 mg of total carotenoid from this fruit can be obtained. Out of the more than 47 reported carotenoids in red mamey, only 34 have a detailed characterization. Conclusion: It is important to continue studying the chemical composition and biological activity of this unique tropical fruit with commercial and nutritional value.
KW - P. sapota
KW - Red mamey
KW - biological activity
KW - characterization
KW - extraction
KW - ketocarotenoid
KW - Carotenoids/chemistry
KW - Fruit
KW - Magnetic Resonance Spectroscopy
KW - Pouteria/chemistry
KW - Chromatography, High Pressure Liquid
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UR - http://www.scopus.com/inward/citedby.url?scp=85130779833&partnerID=8YFLogxK
U2 - 10.2174/1386207324666210301093711
DO - 10.2174/1386207324666210301093711
M3 - Article
C2 - 33645478
AN - SCOPUS:85130779833
SN - 1386-2073
VL - 25
SP - 1134
EP - 1147
JO - Combinatorial Chemistry and High Throughput Screening
JF - Combinatorial Chemistry and High Throughput Screening
IS - 7
ER -