Production of GABAergic cells

L RUBENSTEIN JOHN; MARINA MIONE; STEWART ANDERSON; THORSTEN STUEHMER; KYUSON YUN

Production of GABAergic cells

L RUBENSTEIN JOHN (Inventor), MARINA MIONE (Inventor), STEWART ANDERSON (Inventor), THORSTEN STUEHMER (Inventor), KYUSON YUN (Inventor)

Research output: Patent

Abstract

The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.

Original language	English (US)
Patent number	US2002151066
IPC	A61K 35/ 12 A N
Priority date	7/5/01
State	Published - Oct 17 2002

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title = "Production of GABAergic cells",

abstract = "The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.",

author = "{RUBENSTEIN JOHN}, L and MARINA MIONE and STEWART ANDERSON and THORSTEN STUEHMER and KYUSON YUN",

year = "2002",

month = oct,

day = "17",

language = "English (US)",

type = "Patent",

note = "US2002151066; A61K 35/ 12 A N",

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TY - PAT

T1 - Production of GABAergic cells

AU - RUBENSTEIN JOHN, L

AU - MIONE, MARINA

AU - ANDERSON, STEWART

AU - STUEHMER, THORSTEN

AU - YUN, KYUSON

PY - 2002/10/17

Y1 - 2002/10/17

N2 - The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.

AB - The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.

M3 - Patent

M1 - US2002151066

ER -

Production of GABAergic cells

Abstract

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