TY - JOUR
T1 - Progesterone receptor-estrogen receptor crosstalk
T2 - A novel insight
AU - Thomas, Christoforos
AU - Gustafsson, Jan Åke
N1 - Publisher Copyright:
© 2015.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.
AB - Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.
UR - http://www.scopus.com/inward/record.url?scp=84940450337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940450337&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2015.08.002
DO - 10.1016/j.tem.2015.08.002
M3 - Short survey
C2 - 26277479
AN - SCOPUS:84940450337
SN - 1043-2760
VL - 26
SP - 453
EP - 454
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -