Abstract
Among 415 patients with parkinsonism, 16 (3.9%) had findings of progressive supranuclear palsy (PSP). This report reviews the clinical features and response to drug therapy in those 16 patients. Anticholinergic drugs failed to benefit any of the 5 patients treated, while presynaptic dopaminergic drugs (Sinemet or amantadine) were beneficial in only 5 of 22 patient trials. Alternatively, dopamine agonists (bromocriptine and pergolide) caused improvement in 9 of 14 patient trials despite the fact that all but 1 of these patients had previously failed to respond to presynaptic dopaminergic drugs. Dopamine agonists such as bromocriptine and pergolide may be useful in some patients with PSP.
Original language | English (US) |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Annals of Neurology |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1983 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology