Pure White Cell Aplasia and Necrotizing Myositis

Peter Geon Kim; Joome Suh; Max W Adelman; Kwadwo Oduro; Erik Williams; Andrew M Brunner; David J Kuter

doi:10.1155/2016/4161679

Pure White Cell Aplasia and Necrotizing Myositis

Peter Geon Kim, Joome Suh, Max W Adelman, Kwadwo Oduro, Erik Williams, Andrew M Brunner, David J Kuter

Research output: Contribution to journal › Article › peer-review

Abstract

Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

Original language	English (US)
Pages (from-to)	4161679
Journal	Case reports in hematology
Volume	2016
DOIs	https://doi.org/10.1155/2016/4161679
State	Published - 2016
Externally published	Yes

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title = "Pure White Cell Aplasia and Necrotizing Myositis",

abstract = "Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.",

author = "Kim, {Peter Geon} and Joome Suh and Adelman, {Max W} and Kwadwo Oduro and Erik Williams and Brunner, {Andrew M} and Kuter, {David J}",

year = "2016",

doi = "10.1155/2016/4161679",

language = "English (US)",

volume = "2016",

pages = "4161679",

journal = "Case reports in hematology",

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T1 - Pure White Cell Aplasia and Necrotizing Myositis

AU - Kim, Peter Geon

AU - Suh, Joome

AU - Adelman, Max W

AU - Oduro, Kwadwo

AU - Williams, Erik

AU - Brunner, Andrew M

AU - Kuter, David J

PY - 2016

Y1 - 2016

N2 - Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

AB - Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

U2 - 10.1155/2016/4161679

DO - 10.1155/2016/4161679

M3 - Article

C2 - 27073704

SN - 2090-6560

VL - 2016

SP - 4161679

JO - Case reports in hematology

JF - Case reports in hematology

ER -

Pure White Cell Aplasia and Necrotizing Myositis

Abstract

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