TY - JOUR
T1 - Pushing the limits of treatment for hepatocellular carcinoma
AU - Jones-Pauley, Michelle
AU - Victor, David W.
AU - Kodali, Sudha
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Purpose of reviewWe review existing and newer strategies for treatment and surveillance of hepatocellular carcinoma (HCC) both pre and postliver transplantation.SummaryHCC is rising in incidence and patients are often diagnosed at later stages. Consequently, there is a need for treatment strategies which include collaboration of multiple specialties. Combinations of locoregional, systemic, and surgical therapies are yielding better postliver transplantation (post-LT) outcomes for patients with HCC than previously seen. Tumor biology (tumor size, number, location, serum markers, response to therapy) can help identify patients who are at high risk for HCC recurrence posttransplantation and may expand transplant eligibility for some patients.
AB - Purpose of reviewWe review existing and newer strategies for treatment and surveillance of hepatocellular carcinoma (HCC) both pre and postliver transplantation.SummaryHCC is rising in incidence and patients are often diagnosed at later stages. Consequently, there is a need for treatment strategies which include collaboration of multiple specialties. Combinations of locoregional, systemic, and surgical therapies are yielding better postliver transplantation (post-LT) outcomes for patients with HCC than previously seen. Tumor biology (tumor size, number, location, serum markers, response to therapy) can help identify patients who are at high risk for HCC recurrence posttransplantation and may expand transplant eligibility for some patients.
KW - hepatocellular carcinoma
KW - liver neoplasms
KW - liver transplantation
KW - neoadjuvant therapy
KW - patient selection
UR - http://www.scopus.com/inward/record.url?scp=85181443103&partnerID=8YFLogxK
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U2 - 10.1097/MOT.0000000000001123
DO - 10.1097/MOT.0000000000001123
M3 - Review article
C2 - 38032256
AN - SCOPUS:85181443103
SN - 1087-2418
VL - 29
SP - 3
EP - 9
JO - Current opinion in organ transplantation
JF - Current opinion in organ transplantation
IS - 1
ER -