TY - JOUR
T1 - Racial/Ethnic Disparities in the Burden of HIV/Cervical Cancer Comorbidity and Related In-hospital Mortality in the USA
AU - Salihu, Hamisu
AU - Dongarwar, Deepa
AU - Ikedionwu, Chioma A.
AU - Shelton, Andrea
AU - Jenkins, China M.
AU - Onyenaka, Collins
AU - Charles, Creaque
AU - Wang, Hongmei
AU - Osemene, Inyang
AU - Harris, Kiydra J.
AU - Kaur, Manvir
AU - Rasmus, Monica
AU - Awosemo, Ololade
AU - Milton, Shirlette
AU - Estill, Sonnice
AU - Adebusuyi, Tolulope
AU - Gao, Xiuqing
AU - Mbye, Ya Fatou N.
AU - Chen, Yuan
AU - Olaleye, Omonike A.
N1 - Funding Information:
Research funding support was provided by the US Department of Health and Human Services, Health Resources and Services Administration for the Maternal and Child Health Pipeline Training Program: TSU-BCM Maternal and Child Health Student Training for Academic Readiness and Success (MCH STARS) Undergraduate Fellowship Program, Grant No: T16MC29831; and partially funded by the National Institute of Health, Research Centers in Minority Institutes Program (RCMI, grant number G12MD007605).
Publisher Copyright:
© 2020, W. Montague Cobb-NMA Health Institute.
PY - 2021/2
Y1 - 2021/2
N2 - Objective: The purpose of this study was to determine whether cervical cancer is a risk factor for early mortality among women with HIV and whether racial/ethnic disparity predicted in-hospital death among women living with HIV and diagnosed with cervical cancer. Methods: We conducted a population-based study using the National Inpatient Sample (NIS) database comprising hospitalized HIV-positive women with or without cervical cancer diagnosis, from 2003 through 2015. We compared trends in the rates of cervical cancer, in-hospital death, and years of potential life lost (YPLL) by race/ethnicity. Results: We identified 2,613,696 women with HIV, and among them, 5398 had cervical cancer. The prevalence of cervical cancer (per 10,000) was 9.3 for NH-Whites, 30.9 among NH-Blacks, and 30.2 for Hispanics. Rates of cervical cancer over time diminished significantly only among NH-Whites (average annual percent change (AAPC), − 5.8 (− 9.7, − 1.8)), and YPLL in women with cervical cancer decreased significantly only in NH-Whites (AAPC, − 6.2 (− 10.1, − 2.0)). Cervical cancer was associated with increased odds of in-hospital death overall (OR 2.24 (1.59–3.15)) and among NH-Blacks (OR 2.03 (1.30–3.18)) only. Conclusions: NH-Blacks and Hispanics with HIV remain at increased risk for concurrent diagnosis of cervical cancer compared with NH-Whites. Moreover, NH-Black women with HIV and cervical cancer are at greatest risk for in-hospital death. The findings emphasize the need for a more robust prevention strategy among minority women to reduce the high burden of HIV/cervical cancer and related mortality.
AB - Objective: The purpose of this study was to determine whether cervical cancer is a risk factor for early mortality among women with HIV and whether racial/ethnic disparity predicted in-hospital death among women living with HIV and diagnosed with cervical cancer. Methods: We conducted a population-based study using the National Inpatient Sample (NIS) database comprising hospitalized HIV-positive women with or without cervical cancer diagnosis, from 2003 through 2015. We compared trends in the rates of cervical cancer, in-hospital death, and years of potential life lost (YPLL) by race/ethnicity. Results: We identified 2,613,696 women with HIV, and among them, 5398 had cervical cancer. The prevalence of cervical cancer (per 10,000) was 9.3 for NH-Whites, 30.9 among NH-Blacks, and 30.2 for Hispanics. Rates of cervical cancer over time diminished significantly only among NH-Whites (average annual percent change (AAPC), − 5.8 (− 9.7, − 1.8)), and YPLL in women with cervical cancer decreased significantly only in NH-Whites (AAPC, − 6.2 (− 10.1, − 2.0)). Cervical cancer was associated with increased odds of in-hospital death overall (OR 2.24 (1.59–3.15)) and among NH-Blacks (OR 2.03 (1.30–3.18)) only. Conclusions: NH-Blacks and Hispanics with HIV remain at increased risk for concurrent diagnosis of cervical cancer compared with NH-Whites. Moreover, NH-Black women with HIV and cervical cancer are at greatest risk for in-hospital death. The findings emphasize the need for a more robust prevention strategy among minority women to reduce the high burden of HIV/cervical cancer and related mortality.
KW - Cervical cancer
KW - HIV
KW - Healthcare disparities
KW - Racial disparities
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U2 - 10.1007/s40615-020-00751-5
DO - 10.1007/s40615-020-00751-5
M3 - Article
C2 - 32378158
AN - SCOPUS:85084468680
SN - 2197-3792
VL - 8
SP - 24
EP - 32
JO - Journal of Racial and Ethnic Health Disparities
JF - Journal of Racial and Ethnic Health Disparities
IS - 1
ER -