Radiation Therapy in Ocular Melanoma

Radiotherapy has an established role in multiple settings in the treatment of uveal melanoma, initially emerging as an effective treatment option that can spare both globe and visual function. Delivery modalities include eye plaque brachytherapy, proton/particle beam therapy, and photon-based treatments. This section reviews the indications for radiotherapy, compares different radiotherapy modalities, and discusses outcome measures following radiotherapy for uveal melanoma. Local recurrence in uveal melanoma is associated with distant metastasis and mortality. Thus, an understanding of the different radiotherapy modalities and factors to optimize local control has impactful ramifications.