TY - GEN
T1 - Real-time tagless monitoring of cell viability using patch-clamp microdevices
AU - Pathak, Pushparaj
AU - Zhao, Hong
AU - Gong, Zhongcheng
AU - Nie, Fang
AU - Zhang, Tianhua
AU - Wong, Stephen
AU - Que, Long
PY - 2010
Y1 - 2010
N2 - Real-time tagless monitoring of cell viability using patch-clamp microdevices is reported and validated by using fluorescence imaging techniques for the first time. Specifically, human breast cancer cells MDA-MB-231 have been used for these studies. Systematic experiments on these cells found that the impedance change of captured cells by the micro-electrodes is a valid indicator of cell's living or death, which might provide an efficient way to monitor the drug effects on cells, thereby benefiting high throughput drug screen and discovery process.
AB - Real-time tagless monitoring of cell viability using patch-clamp microdevices is reported and validated by using fluorescence imaging techniques for the first time. Specifically, human breast cancer cells MDA-MB-231 have been used for these studies. Systematic experiments on these cells found that the impedance change of captured cells by the micro-electrodes is a valid indicator of cell's living or death, which might provide an efficient way to monitor the drug effects on cells, thereby benefiting high throughput drug screen and discovery process.
UR - http://www.scopus.com/inward/record.url?scp=78650871422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650871422&partnerID=8YFLogxK
U2 - 10.1109/ICSENS.2010.5690086
DO - 10.1109/ICSENS.2010.5690086
M3 - Conference contribution
AN - SCOPUS:78650871422
SN - 9781424481682
T3 - Proceedings of IEEE Sensors
SP - 2482
EP - 2485
BT - IEEE Sensors 2010 Conference, SENSORS 2010
T2 - 9th IEEE Sensors Conference 2010, SENSORS 2010
Y2 - 1 November 2010 through 4 November 2010
ER -