Abstract
The development of receptor-targeted therapeutic agents has been initiated primarily to limit the distribution of toxic drugs to only the pathologic cells, thus minimizing collateral damage to normal cells. Receptor-mediated drug delivery can also enable otherwise membrane-impermeable drugs to enter target cells by receptor-mediated endocytosis, or it can induce desirable changes in cell behavior by activating a receptor's normal signaling pathway. This chapter begins by summarizing the basic characteristics of the receptor-mediated endocytosis process. It then elaborates on two important characteristics for selection of a receptor for drug delivery: receptor specificity and internalization/recycling. While the ligand, linker, and drug can all take on a diversity of sizes, shapes, and chemistries, a few fundamental principles can be followed to enhance therapeutic efficacy. The chapter describes the preferred characteristics of both the ligand and the drug. It also illustrates the techniques of folate-targeted drug delivery, folate-targeted radiodiagnostic imaging, chemotherapy, and immunotherapy.
Original language | English (US) |
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Title of host publication | Drug Delivery |
Subtitle of host publication | Principles and Applications: Second Edition |
Editors | B. Wang, L Hu, T. J. Siahaan |
Publisher | Wiley |
Pages | 451-474 |
Number of pages | 24 |
ISBN (Electronic) | 9781118833322 |
ISBN (Print) | 9781118833360 |
DOIs | |
State | Published - Mar 25 2016 |
Keywords
- Folate-targeted chemotherapy
- Folate-targeted drug delivery
- Folate-targeted immunotherapy
- Folate-targeted radiodiagnostic imaging
- Ligand
- Receptor specificity
- Receptor-mediated drug delivery
- Receptor-mediated endocytosis
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
- Engineering(all)
- Medicine(all)