Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts

S. H. Gianturco; F. B. Brown; Antonio Gotto; W. A. Bradley

Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts

S. H. Gianturco, F. B. Brown, Antonio Gotto, W. A. Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

Hypertriglyceridemic VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by the high affinity LDL receptor-mediated pathway; by contrast, normal VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by nonspecific, nonsaturable routes; and of the normal VLDL subclasses, only the smallest S(f) 20-60 fraction is bound and internalized via the LDL pathway.

Original language	English (US)
Pages (from-to)	984-993
Number of pages	10
Journal	Journal of lipid research
Volume	23
Issue number	7
State	Published - 1982

ASJC Scopus subject areas

Biochemistry
Endocrinology
Cell Biology

Cite this

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abstract = "Hypertriglyceridemic VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by the high affinity LDL receptor-mediated pathway; by contrast, normal VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by nonspecific, nonsaturable routes; and of the normal VLDL subclasses, only the smallest S(f) 20-60 fraction is bound and internalized via the LDL pathway.",

author = "Gianturco, {S. H.} and Brown, {F. B.} and Antonio Gotto and Bradley, {W. A.}",

year = "1982",

language = "English (US)",

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journal = "Journal of lipid research",

issn = "0022-2275",

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AU - Gianturco, S. H.

AU - Brown, F. B.

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AU - Bradley, W. A.

PY - 1982

Y1 - 1982

N2 - Hypertriglyceridemic VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by the high affinity LDL receptor-mediated pathway; by contrast, normal VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by nonspecific, nonsaturable routes; and of the normal VLDL subclasses, only the smallest S(f) 20-60 fraction is bound and internalized via the LDL pathway.

AB - Hypertriglyceridemic VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by the high affinity LDL receptor-mediated pathway; by contrast, normal VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by nonspecific, nonsaturable routes; and of the normal VLDL subclasses, only the smallest S(f) 20-60 fraction is bound and internalized via the LDL pathway.

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ER -

Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts

Abstract

ASJC Scopus subject areas

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