Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte; Sven Brandau; Shu Hsia Chen; Mario P. Colombo; Alan B. Frey; Tim F. Greten; Susanna Mandruzzato; Peter J. Murray; Augusto Ochoa; Suzanne Ostrand-Rosenberg; Paulo C. Rodriguez; Antonio Sica; Viktor Umansky; Robert H. Vonderheide; Dmitry I. Gabrilovich

doi:10.1038/ncomms12150

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte, Sven Brandau, Shu Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich

Research output: Contribution to journal › Review article › peer-review

1909 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

Original language	English (US)
Article number	12150
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms12150
State	Published - Jul 6 2016

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Bronte, V., Brandau, S., Chen, S. H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., Rodriguez, P. C., Sica, A., Umansky, V., Vonderheide, R. H., & Gabrilovich, D. I. (2016). Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 7, Article 12150. https://doi.org/10.1038/ncomms12150

Bronte, V, Brandau, S, Chen, SH, Colombo, MP, Frey, AB, Greten, TF, Mandruzzato, S, Murray, PJ, Ochoa, A, Ostrand-Rosenberg, S, Rodriguez, PC, Sica, A, Umansky, V, Vonderheide, RH & Gabrilovich, DI 2016, 'Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards', Nature Communications, vol. 7, 12150. https://doi.org/10.1038/ncomms12150

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abstract = "Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.",

author = "Vincenzo Bronte and Sven Brandau and Chen, {Shu Hsia} and Colombo, {Mario P.} and Frey, {Alan B.} and Greten, {Tim F.} and Susanna Mandruzzato and Murray, {Peter J.} and Augusto Ochoa and Suzanne Ostrand-Rosenberg and Rodriguez, {Paulo C.} and Antonio Sica and Viktor Umansky and Vonderheide, {Robert H.} and Gabrilovich, {Dmitry I.}",

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AU - Bronte, Vincenzo

AU - Brandau, Sven

AU - Chen, Shu Hsia

AU - Colombo, Mario P.

AU - Frey, Alan B.

AU - Greten, Tim F.

AU - Mandruzzato, Susanna

AU - Murray, Peter J.

AU - Ochoa, Augusto

AU - Ostrand-Rosenberg, Suzanne

AU - Rodriguez, Paulo C.

AU - Sica, Antonio

AU - Umansky, Viktor

AU - Vonderheide, Robert H.

AU - Gabrilovich, Dmitry I.

PY - 2016/7/6

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N2 - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

AB - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Abstract

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