Regenerating the damaged central nervous system

P. J. Horner; F. H. Gage

doi:10.1038/35039559

Regenerating the damaged central nervous system

P. J. Horner, F. H. Gage

Center for Neuroregeneration

Research output: Contribution to journal › Review article › peer-review

707 Scopus citations

Abstract

It is self-evident that the adult mammalian brain and spinal cord do not regenerate after injury, but recent discoveries have forced a reconsideration of this accepted principle. Advances in our understanding of how the brain develops have provided a rough blueprint for how we may bring about regeneration in the damaged brain. Studies in developmental neurobiology, intracellular signalling and neuroimmunology are bringing the regeneration field closer to success. Notwithstanding these advances, clear and indisputable evidence for adult functional regeneration remains to be shown.

Original language	English (US)
Pages (from-to)	963-970
Number of pages	8
Journal	Nature
Volume	407
Issue number	6807
DOIs	https://doi.org/10.1038/35039559
State	Published - Oct 26 2000

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Regenerating the damaged central nervous system

Abstract

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