Regulation of B-cell activation by CD45: a question of mechanism

Louis B. Justement; Vergil K. Brown; Jiejian Lin

doi:10.1016/0167-5699(94)90268-2

Regulation of B-cell activation by CD45: a question of mechanism

Louis B. Justement, Vergil K. Brown, Jiejian Lin

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43 Scopus citations

Abstract

Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?

Original language	English (US)
Pages (from-to)	399-406
Number of pages	8
Journal	Immunology Today
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/0167-5699(94)90268-2
State	Published - Sep 1994

ASJC Scopus subject areas

Immunology

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title = "Regulation of B-cell activation by CD45: a question of mechanism",

abstract = "Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?",

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AB - Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?

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Regulation of B-cell activation by CD45: a question of mechanism

Abstract

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