TY - JOUR
T1 - Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts
AU - Amacher, David E.
AU - Lieberman, Michael W.
PY - 1977/1/10
Y1 - 1977/1/10
N2 - Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.
AB - Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.
UR - http://www.scopus.com/inward/record.url?scp=0017614125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017614125&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(77)91406-1
DO - 10.1016/0006-291X(77)91406-1
M3 - Article
C2 - 836285
AN - SCOPUS:0017614125
SN - 0006-291X
VL - 74
SP - 285
EP - 290
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -