Abstract
Tumors of many histological types can arise from the kidney. However, only a few account for the majority. Renal cell carcinoma (RCC) and nephroblastoma account for more than 80% of the renal tumors in adults and children, respectively. The Light microscopic morphology has been the foundation for tumor classification. More recently, the protein profiles, chromosomal changes, and pathogenic gene mutation associated with, or responsible for, several histological tumor types were elucidated. These novel findings help refine the tumor classification, elucidate the molecular mechanism of tumor formation, and define molecular targets for tumor-specific therapy. This article provides an overview of renal neoplasms and focuses on RCC, benign renal neoplasms, and nephroblastoma, with an emphasis on pathobiological and molecular attributes.
| Original language | English (US) |
|---|---|
| Title of host publication | Pathobiology of Human Disease |
| Subtitle of host publication | A Dynamic Encyclopedia of Disease Mechanisms |
| Publisher | Elsevier Inc. |
| Pages | 2869-2899 |
| Number of pages | 31 |
| ISBN (Electronic) | 9780123864567 |
| ISBN (Print) | 9780123864574 |
| DOIs | |
| State | Published - Jan 1 2014 |
Keywords
- Benign renal tumors
- Chromosomal abnormaLities
- Epidemiology
- Etiopathogenesis
- FamiLial renal cancers
- Fluorescent in situ hybridization
- Immunohistochemistry
- Molecular changes
- Nephroblastoma
- Pathobiology
- Pathogenesis
- Pediatric renal tumors
- Renal cell carcinoma
- Renal epitheLial tumors
- Risk factors
ASJC Scopus subject areas
- Medicine(all)